A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.

<h4>Background</h4>Many computed tomography (CT) studies have reported that lipid-rich, presumably rupture-prone atherosclerotic plaques can be characterized according to their Hounsfield Unit (HU) value. However, the published HU-based characterization criteria vary considerably. The pr...

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Autores principales:	Wisnumurti Kristanto, Peter M A van Ooijen, Marijke C Jansen-van der Weide, Rozemarijn Vliegenthart, Matthijs Oudkerk
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa6decbca4474c91ad9ee0a7886fa6c5
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spelling	oai:doaj.org-article:fa6decbca4474c91ad9ee0a7886fa6c52021-11-18T08:57:11ZA meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.1932-620310.1371/journal.pone.0073460https://doaj.org/article/fa6decbca4474c91ad9ee0a7886fa6c52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24019924/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Many computed tomography (CT) studies have reported that lipid-rich, presumably rupture-prone atherosclerotic plaques can be characterized according to their Hounsfield Unit (HU) value. However, the published HU-based characterization criteria vary considerably. The present study aims to systematically analyze these values and empirically derive a hierarchical classification of the HU-based criteria which can be referred in clinical situation.<h4>Material and methods</h4>A systematic search in PubMed and Embase for publications with HU-criteria to characterize lipid-rich and fibrous atherosclerotic plaques resulted in 36 publications, published between 1998 and 2011. The HU-criteria were systematically analyzed based on the characteristics of the reporting study. Significant differences between HU-criteria were checked using Student's t-test. Subsequently, a hierarchical classification of HU-criteria was developed based on the respective study characteristics.<h4>Results</h4>No correlation was found between HU-criteria and the reported lumen contrast-enhancement. Significant differences were found for HU-criteria when pooled according to the respective study characteristics: examination type, vessel type, CT-vendor, detector-rows, voltage-setting, and collimation-width. The hierarchical classification resulted in 21 and 22 CT attenuation value categories, for lipid-rich and fibrous plaque, respectively. More than 50% of the hierarchically classified HU-criteria were significantly different.<h4>Conclusion</h4>In conclusion, variations in the reported CT attenuation values for lipid-rich and fibrous plaque are so large that generalized values are unreliable for clinical use. The proposed hierarchical classification can be used to determine reference CT attenuation values of lipid-rich and fibrous plaques for the local setting.Wisnumurti KristantoPeter M A van OoijenMarijke C Jansen-van der WeideRozemarijn VliegenthartMatthijs OudkerkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73460 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wisnumurti Kristanto Peter M A van Ooijen Marijke C Jansen-van der Weide Rozemarijn Vliegenthart Matthijs Oudkerk A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.
description	<h4>Background</h4>Many computed tomography (CT) studies have reported that lipid-rich, presumably rupture-prone atherosclerotic plaques can be characterized according to their Hounsfield Unit (HU) value. However, the published HU-based characterization criteria vary considerably. The present study aims to systematically analyze these values and empirically derive a hierarchical classification of the HU-based criteria which can be referred in clinical situation.<h4>Material and methods</h4>A systematic search in PubMed and Embase for publications with HU-criteria to characterize lipid-rich and fibrous atherosclerotic plaques resulted in 36 publications, published between 1998 and 2011. The HU-criteria were systematically analyzed based on the characteristics of the reporting study. Significant differences between HU-criteria were checked using Student's t-test. Subsequently, a hierarchical classification of HU-criteria was developed based on the respective study characteristics.<h4>Results</h4>No correlation was found between HU-criteria and the reported lumen contrast-enhancement. Significant differences were found for HU-criteria when pooled according to the respective study characteristics: examination type, vessel type, CT-vendor, detector-rows, voltage-setting, and collimation-width. The hierarchical classification resulted in 21 and 22 CT attenuation value categories, for lipid-rich and fibrous plaque, respectively. More than 50% of the hierarchically classified HU-criteria were significantly different.<h4>Conclusion</h4>In conclusion, variations in the reported CT attenuation values for lipid-rich and fibrous plaque are so large that generalized values are unreliable for clinical use. The proposed hierarchical classification can be used to determine reference CT attenuation values of lipid-rich and fibrous plaques for the local setting.
format	article
author	Wisnumurti Kristanto Peter M A van Ooijen Marijke C Jansen-van der Weide Rozemarijn Vliegenthart Matthijs Oudkerk
author_facet	Wisnumurti Kristanto Peter M A van Ooijen Marijke C Jansen-van der Weide Rozemarijn Vliegenthart Matthijs Oudkerk
author_sort	Wisnumurti Kristanto
title	A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.
title_short	A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.
title_full	A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.
title_fullStr	A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.
title_full_unstemmed	A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.
title_sort	meta analysis and hierarchical classification of hu-based atherosclerotic plaque characterization criteria.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fa6decbca4474c91ad9ee0a7886fa6c5
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A meta analysis and hierarchical classification of HU-based atherosclerotic plaque characterization criteria.

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