Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model

Amr Awara,1 Ayman Atiba,2 Duaa Helal,3 Hazem Elbedewy1 1Ophthalmology Department, Tanta University, Tanta, Egypt; 2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt; 3Pathology Department, Tanta University, Tanta, EgyptC...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Awara A, Atiba A, Helal D, Elbedewy H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	eye allergy cyclosporine a eosinophilia subconjunctival. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fa6e2818571b477594e2efe420b93a97
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa6e2818571b477594e2efe420b93a97
record_format	dspace
spelling	oai:doaj.org-article:fa6e2818571b477594e2efe420b93a972021-12-02T09:59:25ZEffectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model1177-5483https://doaj.org/article/fa6e2818571b477594e2efe420b93a972020-02-01T00:00:00Zhttps://www.dovepress.com/effectiveness-of-subconjunctival-cyclosporine-in-treatment-of-acute-al-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Amr Awara,1 Ayman Atiba,2 Duaa Helal,3 Hazem Elbedewy1 1Ophthalmology Department, Tanta University, Tanta, Egypt; 2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt; 3Pathology Department, Tanta University, Tanta, EgyptCorrespondence: Amr AwaraOphthalmology Department, Tanta University, Tanta 31511, EgyptTel +2-01274005384Fax +20403415008Email amrawara@gmail.comBackground: Eye allergy is widely spread worldwide. The treatment includes topical anti-histamines, steroids and non-steroidal drugs. Steroids are the first choice by many ophthalmologists, but unfortunately they may cause serious side effects. Cyclosporine A (CsA) is an immunomodulator drug that can improve eye allergy and reduce the need for steroids; however, topical preparation of CsA is difficult because of the lipophilic nature of the drug.Methods: An experimental study included 16 rats with induced allergy were divided into 2 groups. Group 1: allergic non-treated (6 rats), and Group 2: allergic treated with 0.5 mL subconjunctival CsA 1% (10 rats). Half of each group was sacrificed at 24 hrs and the other half at 1 week. Conjunctival hyperemia and eosinophilic cell count were assessed at each time.Results: Group 2 (CsA treated) showed significantly lower hyperemia score and eosinophilic count at both 24 hrs and 1 week. No ocular complications were noted.Conclusion: Subconjunctival CsA was safe and effective in treating ocular allergy through improving conjunctival hyperemia and reducing eosinophilic cell count with no significant ocular side effects.Keywords: eye allergy, cyclosporine A, eosinophilia, subconjunctivalAwara AAtiba AHelal DElbedewy HDove Medical Pressarticleeye allergycyclosporine aeosinophiliasubconjunctival.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 431-435 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	eye allergy cyclosporine a eosinophilia subconjunctival. Ophthalmology RE1-994
spellingShingle	eye allergy cyclosporine a eosinophilia subconjunctival. Ophthalmology RE1-994 Awara A Atiba A Helal D Elbedewy H Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model
description	Amr Awara,1 Ayman Atiba,2 Duaa Helal,3 Hazem Elbedewy1 1Ophthalmology Department, Tanta University, Tanta, Egypt; 2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt; 3Pathology Department, Tanta University, Tanta, EgyptCorrespondence: Amr AwaraOphthalmology Department, Tanta University, Tanta 31511, EgyptTel +2-01274005384Fax +20403415008Email amrawara@gmail.comBackground: Eye allergy is widely spread worldwide. The treatment includes topical anti-histamines, steroids and non-steroidal drugs. Steroids are the first choice by many ophthalmologists, but unfortunately they may cause serious side effects. Cyclosporine A (CsA) is an immunomodulator drug that can improve eye allergy and reduce the need for steroids; however, topical preparation of CsA is difficult because of the lipophilic nature of the drug.Methods: An experimental study included 16 rats with induced allergy were divided into 2 groups. Group 1: allergic non-treated (6 rats), and Group 2: allergic treated with 0.5 mL subconjunctival CsA 1% (10 rats). Half of each group was sacrificed at 24 hrs and the other half at 1 week. Conjunctival hyperemia and eosinophilic cell count were assessed at each time.Results: Group 2 (CsA treated) showed significantly lower hyperemia score and eosinophilic count at both 24 hrs and 1 week. No ocular complications were noted.Conclusion: Subconjunctival CsA was safe and effective in treating ocular allergy through improving conjunctival hyperemia and reducing eosinophilic cell count with no significant ocular side effects.Keywords: eye allergy, cyclosporine A, eosinophilia, subconjunctival
format	article
author	Awara A Atiba A Helal D Elbedewy H
author_facet	Awara A Atiba A Helal D Elbedewy H
author_sort	Awara A
title	Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model
title_short	Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model
title_full	Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model
title_fullStr	Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model
title_full_unstemmed	Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model
title_sort	effectiveness of subconjunctival cyclosporine in treatment of acute allergic conjunctivitis in a rat-model
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fa6e2818571b477594e2efe420b93a97
work_keys_str_mv	AT awaraa effectivenessofsubconjunctivalcyclosporineintreatmentofacuteallergicconjunctivitisinaratmodel AT atibaa effectivenessofsubconjunctivalcyclosporineintreatmentofacuteallergicconjunctivitisinaratmodel AT helald effectivenessofsubconjunctivalcyclosporineintreatmentofacuteallergicconjunctivitisinaratmodel AT elbedewyh effectivenessofsubconjunctivalcyclosporineintreatmentofacuteallergicconjunctivitisinaratmodel
_version_	1718397863437795328

Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model

Ejemplares similares