Reward prediction error in the ERP following unconditioned aversive stimuli

Abstract Reinforcement learning in humans and other animals is driven by reward prediction errors: deviations between the amount of reward or punishment initially expected and that which is obtained. Temporal difference methods of reinforcement learning generate this reward prediction error at the e...

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Autores principales:	Harry J. Stewardson, Thomas D. Sambrook
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa7210a93ea143c9a225a22301881d08
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spelling	oai:doaj.org-article:fa7210a93ea143c9a225a22301881d082021-12-02T19:16:11ZReward prediction error in the ERP following unconditioned aversive stimuli10.1038/s41598-021-99408-42045-2322https://doaj.org/article/fa7210a93ea143c9a225a22301881d082021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99408-4https://doaj.org/toc/2045-2322Abstract Reinforcement learning in humans and other animals is driven by reward prediction errors: deviations between the amount of reward or punishment initially expected and that which is obtained. Temporal difference methods of reinforcement learning generate this reward prediction error at the earliest time at which a revision in reward or punishment likelihood is signalled, for example by a conditioned stimulus. Midbrain dopamine neurons, believed to compute reward prediction errors, generate this signal in response to both conditioned and unconditioned stimuli, as predicted by temporal difference learning. Electroencephalographic recordings of human participants have suggested that a component named the feedback-related negativity (FRN) is generated when this signal is carried to the cortex. If this is so, the FRN should be expected to respond equivalently to conditioned and unconditioned stimuli. However, very few studies have attempted to measure the FRN’s response to unconditioned stimuli. The present study attempted to elicit the FRN in response to a primary aversive stimulus (electric shock) using a design that varied reward prediction error while holding physical intensity constant. The FRN was strongly elicited, but earlier and more transiently than typically seen, suggesting that it may incorporate other processes than the midbrain dopamine system.Harry J. StewardsonThomas D. SambrookNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Harry J. Stewardson Thomas D. Sambrook Reward prediction error in the ERP following unconditioned aversive stimuli
description	Abstract Reinforcement learning in humans and other animals is driven by reward prediction errors: deviations between the amount of reward or punishment initially expected and that which is obtained. Temporal difference methods of reinforcement learning generate this reward prediction error at the earliest time at which a revision in reward or punishment likelihood is signalled, for example by a conditioned stimulus. Midbrain dopamine neurons, believed to compute reward prediction errors, generate this signal in response to both conditioned and unconditioned stimuli, as predicted by temporal difference learning. Electroencephalographic recordings of human participants have suggested that a component named the feedback-related negativity (FRN) is generated when this signal is carried to the cortex. If this is so, the FRN should be expected to respond equivalently to conditioned and unconditioned stimuli. However, very few studies have attempted to measure the FRN’s response to unconditioned stimuli. The present study attempted to elicit the FRN in response to a primary aversive stimulus (electric shock) using a design that varied reward prediction error while holding physical intensity constant. The FRN was strongly elicited, but earlier and more transiently than typically seen, suggesting that it may incorporate other processes than the midbrain dopamine system.
format	article
author	Harry J. Stewardson Thomas D. Sambrook
author_facet	Harry J. Stewardson Thomas D. Sambrook
author_sort	Harry J. Stewardson
title	Reward prediction error in the ERP following unconditioned aversive stimuli
title_short	Reward prediction error in the ERP following unconditioned aversive stimuli
title_full	Reward prediction error in the ERP following unconditioned aversive stimuli
title_fullStr	Reward prediction error in the ERP following unconditioned aversive stimuli
title_full_unstemmed	Reward prediction error in the ERP following unconditioned aversive stimuli
title_sort	reward prediction error in the erp following unconditioned aversive stimuli
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa7210a93ea143c9a225a22301881d08
work_keys_str_mv	AT harryjstewardson rewardpredictionerrorintheerpfollowingunconditionedaversivestimuli AT thomasdsambrook rewardpredictionerrorintheerpfollowingunconditionedaversivestimuli
_version_	1718377008734404608

Reward prediction error in the ERP following unconditioned aversive stimuli

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