Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts

Abstract After a century of investigations, the function of the obligate betaproteobacterial endosymbionts accommodated in leaf nodules of tropical Rubiaceae remained enigmatic. We report that the α-d-glucose analogue (+)-streptol, systemically supplied by mature Ca. Burkholderia kirkii nodules to t...

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Autores principales:	Antri Georgiou, Simon Sieber, Chien-Chi Hsiao, Tatyana Grayfer, Jacob L. Gorenflos López, Karl Gademann, Leo Eberl, Aurélien Bailly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa73c84b271f49648365643bfb033395
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spelling	oai:doaj.org-article:fa73c84b271f49648365643bfb0333952021-11-21T12:23:57ZLeaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts10.1038/s41598-021-01867-22045-2322https://doaj.org/article/fa73c84b271f49648365643bfb0333952021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01867-2https://doaj.org/toc/2045-2322Abstract After a century of investigations, the function of the obligate betaproteobacterial endosymbionts accommodated in leaf nodules of tropical Rubiaceae remained enigmatic. We report that the α-d-glucose analogue (+)-streptol, systemically supplied by mature Ca. Burkholderia kirkii nodules to their Psychotria hosts, exhibits potent and selective root growth inhibiting activity. We provide compelling evidence that (+)-streptol specifically affects meristematic root cells transitioning to anisotropic elongation by disrupting cell wall organization in a mechanism of action that is distinct from canonical cellulose biosynthesis inhibitors. We observed no inhibitory or cytotoxic effects on organisms other than seed plants, further suggesting (+)-streptol as a bona fide allelochemical. We propose that the suppression of growth of plant competitors is a major driver of the formation and maintenance of the Psychotria–Burkholderia association. In addition to potential agricultural applications as a herbicidal agent, (+)-streptol might also prove useful to dissect plant cell and organ growth processes.Antri GeorgiouSimon SieberChien-Chi HsiaoTatyana GrayferJacob L. Gorenflos LópezKarl GademannLeo EberlAurélien BaillyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antri Georgiou Simon Sieber Chien-Chi Hsiao Tatyana Grayfer Jacob L. Gorenflos López Karl Gademann Leo Eberl Aurélien Bailly Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
description	Abstract After a century of investigations, the function of the obligate betaproteobacterial endosymbionts accommodated in leaf nodules of tropical Rubiaceae remained enigmatic. We report that the α-d-glucose analogue (+)-streptol, systemically supplied by mature Ca. Burkholderia kirkii nodules to their Psychotria hosts, exhibits potent and selective root growth inhibiting activity. We provide compelling evidence that (+)-streptol specifically affects meristematic root cells transitioning to anisotropic elongation by disrupting cell wall organization in a mechanism of action that is distinct from canonical cellulose biosynthesis inhibitors. We observed no inhibitory or cytotoxic effects on organisms other than seed plants, further suggesting (+)-streptol as a bona fide allelochemical. We propose that the suppression of growth of plant competitors is a major driver of the formation and maintenance of the Psychotria–Burkholderia association. In addition to potential agricultural applications as a herbicidal agent, (+)-streptol might also prove useful to dissect plant cell and organ growth processes.
format	article
author	Antri Georgiou Simon Sieber Chien-Chi Hsiao Tatyana Grayfer Jacob L. Gorenflos López Karl Gademann Leo Eberl Aurélien Bailly
author_facet	Antri Georgiou Simon Sieber Chien-Chi Hsiao Tatyana Grayfer Jacob L. Gorenflos López Karl Gademann Leo Eberl Aurélien Bailly
author_sort	Antri Georgiou
title	Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
title_short	Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
title_full	Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
title_fullStr	Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
title_full_unstemmed	Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
title_sort	leaf nodule endosymbiotic burkholderia confer targeted allelopathy to their psychotria hosts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa73c84b271f49648365643bfb033395
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Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts

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