Vitamin D and inflammatory diseases

Kai Yin, Devendra K Agrawal Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA Abstract: Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation...

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Autores principales:	Yin K, Agrawal DK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/fa73e04914114f038a6904f7edf24103
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spelling	oai:doaj.org-article:fa73e04914114f038a6904f7edf241032021-12-02T02:11:15ZVitamin D and inflammatory diseases1178-7031https://doaj.org/article/fa73e04914114f038a6904f7edf241032014-05-01T00:00:00Zhttp://www.dovepress.com/vitamin-d-and-inflammatory-diseases-a17054https://doaj.org/toc/1178-7031 Kai Yin, Devendra K Agrawal Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA Abstract: Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of proinflammatory cells, both of which are crucial for the pathogenesis of inflammatory diseases. Several studies have associated lower vitamin D status with increased risk and unfavorable outcome of acute infections. Vitamin D supplementation bolsters clinical responses to acute infection. Moreover, chronic inflammatory diseases, such as atherosclerosis-related cardiovascular disease, asthma, inflammatory bowel disease, chronic kidney disease, nonalcoholic fatty liver disease, and others, tend to have lower vitamin D status, which may play a pleiotropic role in the pathogenesis of the diseases. In this article, we review recent epidemiological and interventional studies of vitamin D in various inflammatory diseases. The potential mechanisms of vitamin D in regulating immune/inflammatory responses in inflammatory diseases are also discussed. Keywords: asthma, atherosclerosis, chronic kidney disease, inflammatory bowel diseaseYin KAgrawal DKDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2014, Iss default, Pp 69-87 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Yin K Agrawal DK Vitamin D and inflammatory diseases
description	Kai Yin, Devendra K Agrawal Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA Abstract: Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of proinflammatory cells, both of which are crucial for the pathogenesis of inflammatory diseases. Several studies have associated lower vitamin D status with increased risk and unfavorable outcome of acute infections. Vitamin D supplementation bolsters clinical responses to acute infection. Moreover, chronic inflammatory diseases, such as atherosclerosis-related cardiovascular disease, asthma, inflammatory bowel disease, chronic kidney disease, nonalcoholic fatty liver disease, and others, tend to have lower vitamin D status, which may play a pleiotropic role in the pathogenesis of the diseases. In this article, we review recent epidemiological and interventional studies of vitamin D in various inflammatory diseases. The potential mechanisms of vitamin D in regulating immune/inflammatory responses in inflammatory diseases are also discussed. Keywords: asthma, atherosclerosis, chronic kidney disease, inflammatory bowel disease
format	article
author	Yin K Agrawal DK
author_facet	Yin K Agrawal DK
author_sort	Yin K
title	Vitamin D and inflammatory diseases
title_short	Vitamin D and inflammatory diseases
title_full	Vitamin D and inflammatory diseases
title_fullStr	Vitamin D and inflammatory diseases
title_full_unstemmed	Vitamin D and inflammatory diseases
title_sort	vitamin d and inflammatory diseases
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/fa73e04914114f038a6904f7edf24103
work_keys_str_mv	AT yink vitamindandinflammatorydiseases AT agrawaldk vitamindandinflammatorydiseases
_version_	1718402689541341184

Vitamin D and inflammatory diseases

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