Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13

METTL13 (also known as eEF1A-KNMT and FEAT) is a dual methyltransferase reported to target the N-terminus and Lys55 in the eukaryotic translation elongation factor 1 alpha (eEF1A). METTL13-mediated methylation of eEF1A has functional consequences related to translation dynamics and include altered r...

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Autor principal:	Magnus E. Jakobsson
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	post translational modification lysine methylation N-terminal methylation translation enzyme specificity eEF1A Science Q
Acceso en línea:	https://doaj.org/article/fa746b5af7c747a58f040cfdbcd85a7e
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spelling	oai:doaj.org-article:fa746b5af7c747a58f040cfdbcd85a7e2021-11-25T18:10:27ZStructure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL1310.3390/life111111212075-1729https://doaj.org/article/fa746b5af7c747a58f040cfdbcd85a7e2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1121https://doaj.org/toc/2075-1729METTL13 (also known as eEF1A-KNMT and FEAT) is a dual methyltransferase reported to target the N-terminus and Lys55 in the eukaryotic translation elongation factor 1 alpha (eEF1A). METTL13-mediated methylation of eEF1A has functional consequences related to translation dynamics and include altered rate of global protein synthesis and translation of specific codons. Aberrant regulation of METTL13 has been linked to several types of cancer but the precise mechanisms are not yet fully understood. In this article, the current literature related to the structure, activity, and function of METTL13 is systematically reviewed and put into context. The links between METTL13 and diseases, mainly different types of cancer, are also summarized. Finally, key challenges and opportunities for METTL13 research are pinpointed in a prospective outlook.Magnus E. JakobssonMDPI AGarticlepost translational modificationlysine methylationN-terminal methylationtranslationenzyme specificityeEF1AScienceQENLife, Vol 11, Iss 1121, p 1121 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	post translational modification lysine methylation N-terminal methylation translation enzyme specificity eEF1A Science Q
spellingShingle	post translational modification lysine methylation N-terminal methylation translation enzyme specificity eEF1A Science Q Magnus E. Jakobsson Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13
description	METTL13 (also known as eEF1A-KNMT and FEAT) is a dual methyltransferase reported to target the N-terminus and Lys55 in the eukaryotic translation elongation factor 1 alpha (eEF1A). METTL13-mediated methylation of eEF1A has functional consequences related to translation dynamics and include altered rate of global protein synthesis and translation of specific codons. Aberrant regulation of METTL13 has been linked to several types of cancer but the precise mechanisms are not yet fully understood. In this article, the current literature related to the structure, activity, and function of METTL13 is systematically reviewed and put into context. The links between METTL13 and diseases, mainly different types of cancer, are also summarized. Finally, key challenges and opportunities for METTL13 research are pinpointed in a prospective outlook.
format	article
author	Magnus E. Jakobsson
author_facet	Magnus E. Jakobsson
author_sort	Magnus E. Jakobsson
title	Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13
title_short	Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13
title_full	Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13
title_fullStr	Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13
title_full_unstemmed	Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13
title_sort	structure, activity and function of the dual protein lysine and protein n-terminal methyltransferase mettl13
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fa746b5af7c747a58f040cfdbcd85a7e
work_keys_str_mv	AT magnusejakobsson structureactivityandfunctionofthedualproteinlysineandproteinnterminalmethyltransferasemettl13
_version_	1718411538498322432

Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13

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