Endocytosis regulates TDP-43 toxicity and turnover

Impaired turnover of TDP-43 by impaired autophagy or proteasomal function have been suggested to be the cause of TDP-43 accumulation, a hallmark of ALS. Here the authors demonstrate that endocytosis is also important for regulating TDP-43 turnover and toxicity.

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Autores principales:	Guangbo Liu, Alyssa N. Coyne, Fen Pei, Spencer Vaughan, Matthew Chaung, Daniela C. Zarnescu, J. Ross Buchan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa7506d18b1946d4bf2cfee228a8cc57
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spelling	oai:doaj.org-article:fa7506d18b1946d4bf2cfee228a8cc572021-12-02T15:38:31ZEndocytosis regulates TDP-43 toxicity and turnover10.1038/s41467-017-02017-x2041-1723https://doaj.org/article/fa7506d18b1946d4bf2cfee228a8cc572017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02017-xhttps://doaj.org/toc/2041-1723Impaired turnover of TDP-43 by impaired autophagy or proteasomal function have been suggested to be the cause of TDP-43 accumulation, a hallmark of ALS. Here the authors demonstrate that endocytosis is also important for regulating TDP-43 turnover and toxicity.Guangbo LiuAlyssa N. CoyneFen PeiSpencer VaughanMatthew ChaungDaniela C. ZarnescuJ. Ross BuchanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guangbo Liu Alyssa N. Coyne Fen Pei Spencer Vaughan Matthew Chaung Daniela C. Zarnescu J. Ross Buchan Endocytosis regulates TDP-43 toxicity and turnover
description	Impaired turnover of TDP-43 by impaired autophagy or proteasomal function have been suggested to be the cause of TDP-43 accumulation, a hallmark of ALS. Here the authors demonstrate that endocytosis is also important for regulating TDP-43 turnover and toxicity.
format	article
author	Guangbo Liu Alyssa N. Coyne Fen Pei Spencer Vaughan Matthew Chaung Daniela C. Zarnescu J. Ross Buchan
author_facet	Guangbo Liu Alyssa N. Coyne Fen Pei Spencer Vaughan Matthew Chaung Daniela C. Zarnescu J. Ross Buchan
author_sort	Guangbo Liu
title	Endocytosis regulates TDP-43 toxicity and turnover
title_short	Endocytosis regulates TDP-43 toxicity and turnover
title_full	Endocytosis regulates TDP-43 toxicity and turnover
title_fullStr	Endocytosis regulates TDP-43 toxicity and turnover
title_full_unstemmed	Endocytosis regulates TDP-43 toxicity and turnover
title_sort	endocytosis regulates tdp-43 toxicity and turnover
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fa7506d18b1946d4bf2cfee228a8cc57
work_keys_str_mv	AT guangboliu endocytosisregulatestdp43toxicityandturnover AT alyssancoyne endocytosisregulatestdp43toxicityandturnover AT fenpei endocytosisregulatestdp43toxicityandturnover AT spencervaughan endocytosisregulatestdp43toxicityandturnover AT matthewchaung endocytosisregulatestdp43toxicityandturnover AT danielaczarnescu endocytosisregulatestdp43toxicityandturnover AT jrossbuchan endocytosisregulatestdp43toxicityandturnover
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Endocytosis regulates TDP-43 toxicity and turnover

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