The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis

The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis

A major cause of transplanted organ failure is graft arteriosclerosis. Qiuet al. show that a key protease of post-translational SUMO modification, SENP1, is crucial for graft arteriosclerosis by regulating the activity of GATA2 transcription factor in the endothelium, and promoting endothelial infla...

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Autores principales: Cong Qiu, Yuewen Wang, Haige Zhao, Lingfeng Qin, Yanna Shi, Xiaolong Zhu, Lin Song, Xiaofei Zhou, Jian Chen, Hong Zhou, Haifeng Zhang, George Tellides, Wang Min, Luyang Yu
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/fa756d1577ae4cc192e65730f1e3930e
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spelling oai:doaj.org-article:fa756d1577ae4cc192e65730f1e3930e2021-12-02T14:42:24ZThe critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis10.1038/ncomms154262041-1723https://doaj.org/article/fa756d1577ae4cc192e65730f1e3930e2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15426https://doaj.org/toc/2041-1723A major cause of transplanted organ failure is graft arteriosclerosis. Qiuet al. show that a key protease of post-translational SUMO modification, SENP1, is crucial for graft arteriosclerosis by regulating the activity of GATA2 transcription factor in the endothelium, and promoting endothelial inflammation and alloimmunity.Cong QiuYuewen WangHaige ZhaoLingfeng QinYanna ShiXiaolong ZhuLin SongXiaofei ZhouJian ChenHong ZhouHaifeng ZhangGeorge TellidesWang MinLuyang YuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cong Qiu
Yuewen Wang
Haige Zhao
Lingfeng Qin
Yanna Shi
Xiaolong Zhu
Lin Song
Xiaofei Zhou
Jian Chen
Hong Zhou
Haifeng Zhang
George Tellides
Wang Min
Luyang Yu
The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis
description A major cause of transplanted organ failure is graft arteriosclerosis. Qiuet al. show that a key protease of post-translational SUMO modification, SENP1, is crucial for graft arteriosclerosis by regulating the activity of GATA2 transcription factor in the endothelium, and promoting endothelial inflammation and alloimmunity.
format article
author Cong Qiu
Yuewen Wang
Haige Zhao
Lingfeng Qin
Yanna Shi
Xiaolong Zhu
Lin Song
Xiaofei Zhou
Jian Chen
Hong Zhou
Haifeng Zhang
George Tellides
Wang Min
Luyang Yu
author_facet Cong Qiu
Yuewen Wang
Haige Zhao
Lingfeng Qin
Yanna Shi
Xiaolong Zhu
Lin Song
Xiaofei Zhou
Jian Chen
Hong Zhou
Haifeng Zhang
George Tellides
Wang Min
Luyang Yu
author_sort Cong Qiu
title The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis
title_short The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis
title_full The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis
title_fullStr The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis
title_full_unstemmed The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis
title_sort critical role of senp1-mediated gata2 desumoylation in promoting endothelial activation in graft arteriosclerosis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/fa756d1577ae4cc192e65730f1e3930e
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