Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method
Tuberculosis is one of the dangerous infectious diseases, killing over a million people worldwide each year. The search for new dosage forms for the treatment of drug-resistant tuberculosis is an actual task. Biocompatible polymer nanoparticles, in particular bovine serum albumin (BSA), are promisin...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/fa789b672a4d4b8187d1f2a110484491 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:fa789b672a4d4b8187d1f2a110484491 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:fa789b672a4d4b8187d1f2a1104844912021-11-11T18:47:54ZIsoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method10.3390/polym132138082073-4360https://doaj.org/article/fa789b672a4d4b8187d1f2a1104844912021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3808https://doaj.org/toc/2073-4360Tuberculosis is one of the dangerous infectious diseases, killing over a million people worldwide each year. The search for new dosage forms for the treatment of drug-resistant tuberculosis is an actual task. Biocompatible polymer nanoparticles, in particular bovine serum albumin (BSA), are promising drug carriers. Nanoparticle (NP) parameters such as diameter, polydispersity, bioactive substance loading, and NP yield are very important when it comes to drug transport through the bloodstream. The most well-known and widely used first-line anti-tuberculosis drug, isoniazid (INH), is being used as a drug. BSA-INH NPs were obtained by an ethanol desolvation of an aqueous protein solution in the drug presence. The peculiarity of the method is that natural components, namely urea and cysteine, are used for the stabilization of BSA-INH NPs after desolvation. The characteristics of the obtained BSA-INH NPs are significantly affected by the concentration of protein, isoniazid, urea, and cysteine in the solution. The aim of the present study is to investigate the concentration effect of the system reacting components on the parameters of the NPs that are obtained. We have chosen the concentrations of four reacting components, i.e., BSA, isoniazid, urea, and cysteine, as controlling factors and applied the Taguchi method to analyze which concentration of each component has an important effect on BSA-INH NPs characteristics.Yerkeblan TazhbayevAldana GaliyevaTolkyn ZhumagaliyevaMeiram BurkeyevBakhytgul KarimovaMDPI AGarticleproteinsbiopolymersbovine serum albuminnanoparticlesisoniazidTaguchi methodOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3808, p 3808 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
proteins biopolymers bovine serum albumin nanoparticles isoniazid Taguchi method Organic chemistry QD241-441 |
| spellingShingle |
proteins biopolymers bovine serum albumin nanoparticles isoniazid Taguchi method Organic chemistry QD241-441 Yerkeblan Tazhbayev Aldana Galiyeva Tolkyn Zhumagaliyeva Meiram Burkeyev Bakhytgul Karimova Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method |
| description |
Tuberculosis is one of the dangerous infectious diseases, killing over a million people worldwide each year. The search for new dosage forms for the treatment of drug-resistant tuberculosis is an actual task. Biocompatible polymer nanoparticles, in particular bovine serum albumin (BSA), are promising drug carriers. Nanoparticle (NP) parameters such as diameter, polydispersity, bioactive substance loading, and NP yield are very important when it comes to drug transport through the bloodstream. The most well-known and widely used first-line anti-tuberculosis drug, isoniazid (INH), is being used as a drug. BSA-INH NPs were obtained by an ethanol desolvation of an aqueous protein solution in the drug presence. The peculiarity of the method is that natural components, namely urea and cysteine, are used for the stabilization of BSA-INH NPs after desolvation. The characteristics of the obtained BSA-INH NPs are significantly affected by the concentration of protein, isoniazid, urea, and cysteine in the solution. The aim of the present study is to investigate the concentration effect of the system reacting components on the parameters of the NPs that are obtained. We have chosen the concentrations of four reacting components, i.e., BSA, isoniazid, urea, and cysteine, as controlling factors and applied the Taguchi method to analyze which concentration of each component has an important effect on BSA-INH NPs characteristics. |
| format |
article |
| author |
Yerkeblan Tazhbayev Aldana Galiyeva Tolkyn Zhumagaliyeva Meiram Burkeyev Bakhytgul Karimova |
| author_facet |
Yerkeblan Tazhbayev Aldana Galiyeva Tolkyn Zhumagaliyeva Meiram Burkeyev Bakhytgul Karimova |
| author_sort |
Yerkeblan Tazhbayev |
| title |
Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method |
| title_short |
Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method |
| title_full |
Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method |
| title_fullStr |
Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method |
| title_full_unstemmed |
Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method |
| title_sort |
isoniazid—loaded albumin nanoparticles: taguchi optimization method |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/fa789b672a4d4b8187d1f2a110484491 |
| work_keys_str_mv |
AT yerkeblantazhbayev isoniazidloadedalbuminnanoparticlestaguchioptimizationmethod AT aldanagaliyeva isoniazidloadedalbuminnanoparticlestaguchioptimizationmethod AT tolkynzhumagaliyeva isoniazidloadedalbuminnanoparticlestaguchioptimizationmethod AT meiramburkeyev isoniazidloadedalbuminnanoparticlestaguchioptimizationmethod AT bakhytgulkarimova isoniazidloadedalbuminnanoparticlestaguchioptimizationmethod |
| _version_ |
1718431741684744192 |