Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.

<h4>Background</h4>It has been shown that vitamin D is associated with obesity and the development of atherosclerosis. Less is known about this association among adolescents with obesity.<h4>Objectives</h4>To determine the association of vitamin D level and metabolic risk fac...

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Autores principales:	Indah K Murni, Dian C Sulistyoningrum, Danijela Gasevic, Rina Susilowati, Madarina Julia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa805d3156044dcab533d774806a173f
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spelling	oai:doaj.org-article:fa805d3156044dcab533d774806a173f2021-12-02T20:16:53ZSex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.1932-620310.1371/journal.pone.0258617https://doaj.org/article/fa805d3156044dcab533d774806a173f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258617https://doaj.org/toc/1932-6203<h4>Background</h4>It has been shown that vitamin D is associated with obesity and the development of atherosclerosis. Less is known about this association among adolescents with obesity.<h4>Objectives</h4>To determine the association of vitamin D level and metabolic risk factors with carotid intima-media thickness (CIMT) among obese adolescents.<h4>Methods</h4>We conducted a cross-sectional study among obese children aged 15 to 17 years in Yogyakarta, Indonesia. The association of vitamin D and other metabolic risk factors (triglyceride, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), and insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR)) with CIMT was explored by multivariable linear regression models.<h4>Results</h4>Out of 156 obese adolescents, 55.8% were boys. Compared to girls, boys had higher BMI z-score, waist circumference, and HDL-cholesterol. After adjustment for age, sex and second-hand smoke exposure, high HOMA-IR, total cholesterol, LDL-cholesterol and triglyceride levels were associated with higher odds of elevated CIMT. In analyses stratified by sex, a similar trend was observed in boys, while none of the risk factors were associated with CIMT in girls. We observed no association between vitamin D and CIMT.<h4>Conclusions</h4>Hyperinsulinemia, higher total cholesterol and LDL cholesterol were associated with greater odds of elevated CIMT among obese adolescent boys.Indah K MurniDian C SulistyoningrumDanijela GasevicRina SusilowatiMadarina JuliaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258617 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Indah K Murni Dian C Sulistyoningrum Danijela Gasevic Rina Susilowati Madarina Julia Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.
description	<h4>Background</h4>It has been shown that vitamin D is associated with obesity and the development of atherosclerosis. Less is known about this association among adolescents with obesity.<h4>Objectives</h4>To determine the association of vitamin D level and metabolic risk factors with carotid intima-media thickness (CIMT) among obese adolescents.<h4>Methods</h4>We conducted a cross-sectional study among obese children aged 15 to 17 years in Yogyakarta, Indonesia. The association of vitamin D and other metabolic risk factors (triglyceride, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), and insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR)) with CIMT was explored by multivariable linear regression models.<h4>Results</h4>Out of 156 obese adolescents, 55.8% were boys. Compared to girls, boys had higher BMI z-score, waist circumference, and HDL-cholesterol. After adjustment for age, sex and second-hand smoke exposure, high HOMA-IR, total cholesterol, LDL-cholesterol and triglyceride levels were associated with higher odds of elevated CIMT. In analyses stratified by sex, a similar trend was observed in boys, while none of the risk factors were associated with CIMT in girls. We observed no association between vitamin D and CIMT.<h4>Conclusions</h4>Hyperinsulinemia, higher total cholesterol and LDL cholesterol were associated with greater odds of elevated CIMT among obese adolescent boys.
format	article
author	Indah K Murni Dian C Sulistyoningrum Danijela Gasevic Rina Susilowati Madarina Julia
author_facet	Indah K Murni Dian C Sulistyoningrum Danijela Gasevic Rina Susilowati Madarina Julia
author_sort	Indah K Murni
title	Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.
title_short	Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.
title_full	Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.
title_fullStr	Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.
title_full_unstemmed	Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.
title_sort	sex differences in the association of vitamin d and metabolic risk factors with carotid intima-media thickness in obese adolescents.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fa805d3156044dcab533d774806a173f
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Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents.

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