Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

While energy metabolism has been repeatedly linked to ALS, motor neuron metabolism remains poorly studied. Here, authors show that human iPSCs rewire specific metabolic routes when they differentiate into functional motor neurons and that ALS-causing mutations in FUS do not affect energy metabolism.

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Autores principales:	Tijs Vandoorne, Koen Veys, Wenting Guo, Adria Sicart, Katlijn Vints, Ann Swijsen, Matthieu Moisse, Guy Eelen, Natalia V. Gounko, Laura Fumagalli, Raheem Fazal, Christine Germeys, Annelies Quaegebeur, Sarah-Maria Fendt, Peter Carmeliet, Catherine Verfaillie, Philip Van Damme, Bart Ghesquière, Katrien De Bock, Ludo Van Den Bosch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa80c26ad33443938150866628a1b0dd
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spelling	oai:doaj.org-article:fa80c26ad33443938150866628a1b0dd2021-12-02T17:02:07ZDifferentiation but not ALS mutations in FUS rewires motor neuron metabolism10.1038/s41467-019-12099-42041-1723https://doaj.org/article/fa80c26ad33443938150866628a1b0dd2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12099-4https://doaj.org/toc/2041-1723While energy metabolism has been repeatedly linked to ALS, motor neuron metabolism remains poorly studied. Here, authors show that human iPSCs rewire specific metabolic routes when they differentiate into functional motor neurons and that ALS-causing mutations in FUS do not affect energy metabolism.Tijs VandoorneKoen VeysWenting GuoAdria SicartKatlijn VintsAnn SwijsenMatthieu MoisseGuy EelenNatalia V. GounkoLaura FumagalliRaheem FazalChristine GermeysAnnelies QuaegebeurSarah-Maria FendtPeter CarmelietCatherine VerfailliePhilip Van DammeBart GhesquièreKatrien De BockLudo Van Den BoschNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tijs Vandoorne Koen Veys Wenting Guo Adria Sicart Katlijn Vints Ann Swijsen Matthieu Moisse Guy Eelen Natalia V. Gounko Laura Fumagalli Raheem Fazal Christine Germeys Annelies Quaegebeur Sarah-Maria Fendt Peter Carmeliet Catherine Verfaillie Philip Van Damme Bart Ghesquière Katrien De Bock Ludo Van Den Bosch Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
description	While energy metabolism has been repeatedly linked to ALS, motor neuron metabolism remains poorly studied. Here, authors show that human iPSCs rewire specific metabolic routes when they differentiate into functional motor neurons and that ALS-causing mutations in FUS do not affect energy metabolism.
format	article
author	Tijs Vandoorne Koen Veys Wenting Guo Adria Sicart Katlijn Vints Ann Swijsen Matthieu Moisse Guy Eelen Natalia V. Gounko Laura Fumagalli Raheem Fazal Christine Germeys Annelies Quaegebeur Sarah-Maria Fendt Peter Carmeliet Catherine Verfaillie Philip Van Damme Bart Ghesquière Katrien De Bock Ludo Van Den Bosch
author_facet	Tijs Vandoorne Koen Veys Wenting Guo Adria Sicart Katlijn Vints Ann Swijsen Matthieu Moisse Guy Eelen Natalia V. Gounko Laura Fumagalli Raheem Fazal Christine Germeys Annelies Quaegebeur Sarah-Maria Fendt Peter Carmeliet Catherine Verfaillie Philip Van Damme Bart Ghesquière Katrien De Bock Ludo Van Den Bosch
author_sort	Tijs Vandoorne
title	Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
title_short	Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
title_full	Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
title_fullStr	Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
title_full_unstemmed	Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
title_sort	differentiation but not als mutations in fus rewires motor neuron metabolism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fa80c26ad33443938150866628a1b0dd
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Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

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