P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

During embryo development, cell fitness determines survival but how this is regulated is unclear. Here, the authors show that in early embryonic development and stem cells exiting the naive state, cells sense the fitness of their neighbours and trigger p53 to repress mTOR to eliminate a third of cel...

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Autores principales:	Sarah Bowling, Aida Di Gregorio, Margarida Sancho, Sara Pozzi, Marieke Aarts, Massimo Signore, Michael D. Schneider, Juan Pedro Martinez-Barbera, Jesús Gil, Tristan A. Rodríguez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa84dfb29e394c458e23e23541902818
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spelling	oai:doaj.org-article:fa84dfb29e394c458e23e235419028182021-12-02T14:39:46ZP53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development10.1038/s41467-018-04167-y2041-1723https://doaj.org/article/fa84dfb29e394c458e23e235419028182018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04167-yhttps://doaj.org/toc/2041-1723During embryo development, cell fitness determines survival but how this is regulated is unclear. Here, the authors show that in early embryonic development and stem cells exiting the naive state, cells sense the fitness of their neighbours and trigger p53 to repress mTOR to eliminate a third of cells.Sarah BowlingAida Di GregorioMargarida SanchoSara PozziMarieke AartsMassimo SignoreMichael D. SchneiderJuan Pedro Martinez-BarberaJesús GilTristan A. RodríguezNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Bowling Aida Di Gregorio Margarida Sancho Sara Pozzi Marieke Aarts Massimo Signore Michael D. Schneider Juan Pedro Martinez-Barbera Jesús Gil Tristan A. Rodríguez P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
description	During embryo development, cell fitness determines survival but how this is regulated is unclear. Here, the authors show that in early embryonic development and stem cells exiting the naive state, cells sense the fitness of their neighbours and trigger p53 to repress mTOR to eliminate a third of cells.
format	article
author	Sarah Bowling Aida Di Gregorio Margarida Sancho Sara Pozzi Marieke Aarts Massimo Signore Michael D. Schneider Juan Pedro Martinez-Barbera Jesús Gil Tristan A. Rodríguez
author_facet	Sarah Bowling Aida Di Gregorio Margarida Sancho Sara Pozzi Marieke Aarts Massimo Signore Michael D. Schneider Juan Pedro Martinez-Barbera Jesús Gil Tristan A. Rodríguez
author_sort	Sarah Bowling
title	P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
title_short	P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
title_full	P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
title_fullStr	P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
title_full_unstemmed	P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
title_sort	p53 and mtor signalling determine fitness selection through cell competition during early mouse embryonic development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fa84dfb29e394c458e23e23541902818
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P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

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