Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

The risk of developing cancer increases with age. Here, the authors address the contribution of age-dependent accumulation of senescent cells within the tumour stroma compartment and show that senescent cells increase the infiltration of myeloid-derived suppressor cells that inhibit cytotoxic T-cell...

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Autores principales:	Megan K. Ruhland, Andrew J. Loza, Aude-Helene Capietto, Xianmin Luo, Brett L. Knolhoff, Kevin C. Flanagan, Brian A. Belt, Elise Alspach, Kathleen Leahy, Jingqin Luo, Andras Schaffer, John R. Edwards, Gregory Longmore, Roberta Faccio, David G. DeNardo, Sheila A. Stewart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa867a0d00a840c499859677d3888265
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spelling	oai:doaj.org-article:fa867a0d00a840c499859677d38882652021-12-02T14:39:14ZStromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis10.1038/ncomms117622041-1723https://doaj.org/article/fa867a0d00a840c499859677d38882652016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11762https://doaj.org/toc/2041-1723The risk of developing cancer increases with age. Here, the authors address the contribution of age-dependent accumulation of senescent cells within the tumour stroma compartment and show that senescent cells increase the infiltration of myeloid-derived suppressor cells that inhibit cytotoxic T-cells, thus facilitating tumour outgrowth.Megan K. RuhlandAndrew J. LozaAude-Helene CapiettoXianmin LuoBrett L. KnolhoffKevin C. FlanaganBrian A. BeltElise AlspachKathleen LeahyJingqin LuoAndras SchafferJohn R. EdwardsGregory LongmoreRoberta FaccioDavid G. DeNardoSheila A. StewartNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Megan K. Ruhland Andrew J. Loza Aude-Helene Capietto Xianmin Luo Brett L. Knolhoff Kevin C. Flanagan Brian A. Belt Elise Alspach Kathleen Leahy Jingqin Luo Andras Schaffer John R. Edwards Gregory Longmore Roberta Faccio David G. DeNardo Sheila A. Stewart Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
description	The risk of developing cancer increases with age. Here, the authors address the contribution of age-dependent accumulation of senescent cells within the tumour stroma compartment and show that senescent cells increase the infiltration of myeloid-derived suppressor cells that inhibit cytotoxic T-cells, thus facilitating tumour outgrowth.
format	article
author	Megan K. Ruhland Andrew J. Loza Aude-Helene Capietto Xianmin Luo Brett L. Knolhoff Kevin C. Flanagan Brian A. Belt Elise Alspach Kathleen Leahy Jingqin Luo Andras Schaffer John R. Edwards Gregory Longmore Roberta Faccio David G. DeNardo Sheila A. Stewart
author_facet	Megan K. Ruhland Andrew J. Loza Aude-Helene Capietto Xianmin Luo Brett L. Knolhoff Kevin C. Flanagan Brian A. Belt Elise Alspach Kathleen Leahy Jingqin Luo Andras Schaffer John R. Edwards Gregory Longmore Roberta Faccio David G. DeNardo Sheila A. Stewart
author_sort	Megan K. Ruhland
title	Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
title_short	Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
title_full	Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
title_fullStr	Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
title_full_unstemmed	Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
title_sort	stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fa867a0d00a840c499859677d3888265
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Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

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