Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood

Abstract Genetic effects on alcohol use can vary over time but are often examined using longitudinal models that predict a distal outcome at a single time point. The vast majority of these studies predominately examine effects using White, European American (EA) samples or examine the etiology of ge...

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Autores principales:	Kit K. Elam, Thao Ha, Zoe Neale, Fazil Aliev, Danielle Dick, Kathryn Lemery-Chalfant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa872435f86b4b46a37139c6e0b979e8
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spelling	oai:doaj.org-article:fa872435f86b4b46a37139c6e0b979e82021-11-21T12:24:51ZAge varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood10.1038/s41598-021-01923-x2045-2322https://doaj.org/article/fa872435f86b4b46a37139c6e0b979e82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01923-xhttps://doaj.org/toc/2045-2322Abstract Genetic effects on alcohol use can vary over time but are often examined using longitudinal models that predict a distal outcome at a single time point. The vast majority of these studies predominately examine effects using White, European American (EA) samples or examine the etiology of genetic variants identified from EA samples in other racial/ethnic populations, leading to inconclusive findings about genetic effects on alcohol use. The current study examined how genetic influences on alcohol use varied by age across a 15 year period within a diverse ethnic/racial sample of adolescents. Using a multi-ethnic approach, polygenic risk scores were created for African American (AA, n = 192) and EA samples (n = 271) based on racially/ethnically aligned genome wide association studies. Age-varying associations between polygenic scores and alcohol use were examined from age 16 to 30 using time-varying effect models separately for AA and EA samples. Polygenic risk for alcohol use was found to be associated with alcohol use from age 22–27 in the AA sample and from age 24.50 to 29 in the EA sample. Results are discussed relative to the intersection of alcohol use and developmental genetic effects in diverse populations.Kit K. ElamThao HaZoe NealeFazil AlievDanielle DickKathryn Lemery-ChalfantNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kit K. Elam Thao Ha Zoe Neale Fazil Aliev Danielle Dick Kathryn Lemery-Chalfant Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood
description	Abstract Genetic effects on alcohol use can vary over time but are often examined using longitudinal models that predict a distal outcome at a single time point. The vast majority of these studies predominately examine effects using White, European American (EA) samples or examine the etiology of genetic variants identified from EA samples in other racial/ethnic populations, leading to inconclusive findings about genetic effects on alcohol use. The current study examined how genetic influences on alcohol use varied by age across a 15 year period within a diverse ethnic/racial sample of adolescents. Using a multi-ethnic approach, polygenic risk scores were created for African American (AA, n = 192) and EA samples (n = 271) based on racially/ethnically aligned genome wide association studies. Age-varying associations between polygenic scores and alcohol use were examined from age 16 to 30 using time-varying effect models separately for AA and EA samples. Polygenic risk for alcohol use was found to be associated with alcohol use from age 22–27 in the AA sample and from age 24.50 to 29 in the EA sample. Results are discussed relative to the intersection of alcohol use and developmental genetic effects in diverse populations.
format	article
author	Kit K. Elam Thao Ha Zoe Neale Fazil Aliev Danielle Dick Kathryn Lemery-Chalfant
author_facet	Kit K. Elam Thao Ha Zoe Neale Fazil Aliev Danielle Dick Kathryn Lemery-Chalfant
author_sort	Kit K. Elam
title	Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood
title_short	Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood
title_full	Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood
title_fullStr	Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood
title_full_unstemmed	Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood
title_sort	age varying polygenic effects on alcohol use in african americans and european americans from adolescence to adulthood
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa872435f86b4b46a37139c6e0b979e8
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Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood

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