Removal of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine

Abstract Microbial electrochemical technology is emerging as an alternative way of treating waste and converting this directly to electricity. Intensive research on these systems is ongoing but it currently lacks the evaluation of possible environmental transmission of enteric viruses originating fr...

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Autores principales:	Grzegorz Pasternak, John Greenman, Ioannis Ieropoulos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa8a0d78acf04a78b566a8e9f1aea4e9
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spelling	oai:doaj.org-article:fa8a0d78acf04a78b566a8e9f1aea4e92021-12-02T15:08:47ZRemoval of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine10.1038/s41598-019-48128-x2045-2322https://doaj.org/article/fa8a0d78acf04a78b566a8e9f1aea4e92019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48128-xhttps://doaj.org/toc/2045-2322Abstract Microbial electrochemical technology is emerging as an alternative way of treating waste and converting this directly to electricity. Intensive research on these systems is ongoing but it currently lacks the evaluation of possible environmental transmission of enteric viruses originating from the waste stream. In this study, for the first time we investigated this aspect by assessing the removal efficiency of hepatitis B core and surface antigens in cascades of continuous flow microbial fuel cells. The log-reduction (LR) of surface antigen (HBsAg) reached a maximum value of 1.86 ± 0.20 (98.6% reduction), which was similar to the open circuit control and degraded regardless of the recorded current. Core antigen (HBcAg) was much more resistant to treatment and the maximal LR was equal to 0.229 ± 0.028 (41.0% reduction). The highest LR rate observed for HBsAg was 4.66 ± 0.19 h−1 and for HBcAg 0.10 ± 0.01 h−1. Regression analysis revealed correlation between hydraulic retention time, power and redox potential on inactivation efficiency, also indicating electroactive behaviour of biofilm in open circuit control through the snorkel-effect. The results indicate that microbial electrochemical technologies may be successfully applied to reduce the risk of environmental transmission of hepatitis B virus but also open up the possibility of testing other viruses for wider implementation.Grzegorz PasternakJohn GreenmanIoannis IeropoulosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Grzegorz Pasternak John Greenman Ioannis Ieropoulos Removal of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine
description	Abstract Microbial electrochemical technology is emerging as an alternative way of treating waste and converting this directly to electricity. Intensive research on these systems is ongoing but it currently lacks the evaluation of possible environmental transmission of enteric viruses originating from the waste stream. In this study, for the first time we investigated this aspect by assessing the removal efficiency of hepatitis B core and surface antigens in cascades of continuous flow microbial fuel cells. The log-reduction (LR) of surface antigen (HBsAg) reached a maximum value of 1.86 ± 0.20 (98.6% reduction), which was similar to the open circuit control and degraded regardless of the recorded current. Core antigen (HBcAg) was much more resistant to treatment and the maximal LR was equal to 0.229 ± 0.028 (41.0% reduction). The highest LR rate observed for HBsAg was 4.66 ± 0.19 h−1 and for HBcAg 0.10 ± 0.01 h−1. Regression analysis revealed correlation between hydraulic retention time, power and redox potential on inactivation efficiency, also indicating electroactive behaviour of biofilm in open circuit control through the snorkel-effect. The results indicate that microbial electrochemical technologies may be successfully applied to reduce the risk of environmental transmission of hepatitis B virus but also open up the possibility of testing other viruses for wider implementation.
format	article
author	Grzegorz Pasternak John Greenman Ioannis Ieropoulos
author_facet	Grzegorz Pasternak John Greenman Ioannis Ieropoulos
author_sort	Grzegorz Pasternak
title	Removal of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine
title_short	Removal of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine
title_full	Removal of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine
title_fullStr	Removal of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine
title_full_unstemmed	Removal of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine
title_sort	removal of hepatitis b virus surface hbsag and core hbcag antigens using microbial fuel cells producing electricity from human urine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fa8a0d78acf04a78b566a8e9f1aea4e9
work_keys_str_mv	AT grzegorzpasternak removalofhepatitisbvirussurfacehbsagandcorehbcagantigensusingmicrobialfuelcellsproducingelectricityfromhumanurine AT johngreenman removalofhepatitisbvirussurfacehbsagandcorehbcagantigensusingmicrobialfuelcellsproducingelectricityfromhumanurine AT ioannisieropoulos removalofhepatitisbvirussurfacehbsagandcorehbcagantigensusingmicrobialfuelcellsproducingelectricityfromhumanurine
_version_	1718388038147506176

Removal of Hepatitis B virus surface HBsAg and core HBcAg antigens using microbial fuel cells producing electricity from human urine

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