Primary hyperparathyroidism and vitamin D deficiency

Primary hyperparathyroidism (PHPT) is the third most common endocrine disease after diabetes mellitus and thyroid pathology. Recent epidemiological and experimental data have shown that long-term maintenance of low vitamin D levels in the blood can lead to the development of hyperplastic processes i...

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Autores principales:	Gyuzel E. Runova, Olga O. Golounina, Irina V. Glinkina, Valentin V. Fadeev
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	vitamin d primary hyperparathyroidism parathyroid glands 25-hydroxycholecalciferol calcium and phosphorus metabolism Medicine R
Acceso en línea:	https://doaj.org/article/fa8b0bfd96624d7899e8fe7460001fc3
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spelling	oai:doaj.org-article:fa8b0bfd96624d7899e8fe7460001fc32021-12-01T12:22:37ZPrimary hyperparathyroidism and vitamin D deficiency0040-36602309-534210.26442/00403660.2021.10.201081https://doaj.org/article/fa8b0bfd96624d7899e8fe7460001fc32021-10-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/86969/65151https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342Primary hyperparathyroidism (PHPT) is the third most common endocrine disease after diabetes mellitus and thyroid pathology. Recent epidemiological and experimental data have shown that long-term maintenance of low vitamin D levels in the blood can lead to the development of hyperplastic processes in the cells of the parathyroid glands, followed by autonomous production of parathyroid hormone. In PHPT vitamin D insufficiency or deficiency according to various sources occurs with a frequency of 5377% of cases. The literature review indicates more severe disease in patients with concomitant vitamin D deficiency. The expediency of preoperative assessment of vitamin D levels in all patients with PHPT in order to minimize the risk of hypocalcemia after parathyroidectomy is discussed. This article presents the relationship between vitamin D deficiency and PHPT, as well as possible methods for correcting vitamin D deficiency in PHPT. Molecular and cellular mechanisms of the occurrence of pathological processes in the parathyroid glands under conditions of low vitamin D levels are presented.Gyuzel E. RunovaOlga O. GolouninaIrina V. GlinkinaValentin V. Fadeev"Consilium Medicum" Publishing housearticlevitamin dprimary hyperparathyroidismparathyroid glands25-hydroxycholecalciferolcalcium and phosphorus metabolismMedicineRRUТерапевтический архив, Vol 93, Iss 10, Pp 1221-1226 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	vitamin d primary hyperparathyroidism parathyroid glands 25-hydroxycholecalciferol calcium and phosphorus metabolism Medicine R
spellingShingle	vitamin d primary hyperparathyroidism parathyroid glands 25-hydroxycholecalciferol calcium and phosphorus metabolism Medicine R Gyuzel E. Runova Olga O. Golounina Irina V. Glinkina Valentin V. Fadeev Primary hyperparathyroidism and vitamin D deficiency
description	Primary hyperparathyroidism (PHPT) is the third most common endocrine disease after diabetes mellitus and thyroid pathology. Recent epidemiological and experimental data have shown that long-term maintenance of low vitamin D levels in the blood can lead to the development of hyperplastic processes in the cells of the parathyroid glands, followed by autonomous production of parathyroid hormone. In PHPT vitamin D insufficiency or deficiency according to various sources occurs with a frequency of 5377% of cases. The literature review indicates more severe disease in patients with concomitant vitamin D deficiency. The expediency of preoperative assessment of vitamin D levels in all patients with PHPT in order to minimize the risk of hypocalcemia after parathyroidectomy is discussed. This article presents the relationship between vitamin D deficiency and PHPT, as well as possible methods for correcting vitamin D deficiency in PHPT. Molecular and cellular mechanisms of the occurrence of pathological processes in the parathyroid glands under conditions of low vitamin D levels are presented.
format	article
author	Gyuzel E. Runova Olga O. Golounina Irina V. Glinkina Valentin V. Fadeev
author_facet	Gyuzel E. Runova Olga O. Golounina Irina V. Glinkina Valentin V. Fadeev
author_sort	Gyuzel E. Runova
title	Primary hyperparathyroidism and vitamin D deficiency
title_short	Primary hyperparathyroidism and vitamin D deficiency
title_full	Primary hyperparathyroidism and vitamin D deficiency
title_fullStr	Primary hyperparathyroidism and vitamin D deficiency
title_full_unstemmed	Primary hyperparathyroidism and vitamin D deficiency
title_sort	primary hyperparathyroidism and vitamin d deficiency
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/fa8b0bfd96624d7899e8fe7460001fc3
work_keys_str_mv	AT gyuzelerunova primaryhyperparathyroidismandvitaminddeficiency AT olgaogolounina primaryhyperparathyroidismandvitaminddeficiency AT irinavglinkina primaryhyperparathyroidismandvitaminddeficiency AT valentinvfadeev primaryhyperparathyroidismandvitaminddeficiency
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Primary hyperparathyroidism and vitamin D deficiency

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