The MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions

Abstract There are few studies investigate morphologic changes of knee meniscus in vivo mechanical loading and three-dimensions (3D) deformation and displacement of the whole meniscus between in vivo mechanical loading and unloading conditions are still unclear. To investigate the displacements and...

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Autores principales:	Tong Liu, Xianyue Shen, Qingming Ji, Jianlin Xiao, Jianlin Zuo, Zhongli Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa8be69e0f1f438dbaaf1746697dc155
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spelling	oai:doaj.org-article:fa8be69e0f1f438dbaaf1746697dc1552021-11-14T12:21:25ZThe MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions10.1038/s41598-021-01531-92045-2322https://doaj.org/article/fa8be69e0f1f438dbaaf1746697dc1552021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01531-9https://doaj.org/toc/2045-2322Abstract There are few studies investigate morphologic changes of knee meniscus in vivo mechanical loading and three-dimensions (3D) deformation and displacement of the whole meniscus between in vivo mechanical loading and unloading conditions are still unclear. To investigate the displacements and 3D morphological changes of the menisci under knee weight-bearing and early flexion conditions in healthy adults using a Magnetic Resonance Imaging (MRI)-compatible loading device (a 3.0 T MR imaging system) combined with a newly developed 3D comparison technique. Fifteen healthy volunteers were recruited in this cross-sectional observational study. Each subject underwent MRIs of their dominant right knee in eight different scanning conditions using a 3.0-T MRI scanner with a custom-made MRI-compatible loading device. The knee meniscus images were 3D reconstructed, and dimensional comparisons were made for each meniscal model with baseline (0°-unloaded model). The morphologic changes of the meniscal-anterior horn (AH), body (BD), and posterior horn (PH) regions were expressed as mean positive and negative deviations. The displacements were further investigated, and the meniscal extrusions of different subregions were measured. The morphologic changing patterns of human meniscus under loading and flexions were presented using 3D chromatic maps. The bilateral menisci were generally shifting laterally and posteriorly in most flexion angles and were changing medially and anteriorly under fully extended knee loading conditions. The mean deviations were more significant with loading at 0° of knee flexion, while the PH region in the lateral side changed further posteriorly with loading in 30° flexion. Most of the differences were not significant in other flexion angles between loading conditions. The extrusion of meniscus’s medial body was greater in full extension compared to any other flexing angles. Mechanical loading can significantly deform the menisci in knee extension; however, this effect is limited during knee flexion. Current study can be used as a reference for the evaluations of the integrity in meniscal functions.Tong LiuXianyue ShenQingming JiJianlin XiaoJianlin ZuoZhongli GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tong Liu Xianyue Shen Qingming Ji Jianlin Xiao Jianlin Zuo Zhongli Gao The MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions
description	Abstract There are few studies investigate morphologic changes of knee meniscus in vivo mechanical loading and three-dimensions (3D) deformation and displacement of the whole meniscus between in vivo mechanical loading and unloading conditions are still unclear. To investigate the displacements and 3D morphological changes of the menisci under knee weight-bearing and early flexion conditions in healthy adults using a Magnetic Resonance Imaging (MRI)-compatible loading device (a 3.0 T MR imaging system) combined with a newly developed 3D comparison technique. Fifteen healthy volunteers were recruited in this cross-sectional observational study. Each subject underwent MRIs of their dominant right knee in eight different scanning conditions using a 3.0-T MRI scanner with a custom-made MRI-compatible loading device. The knee meniscus images were 3D reconstructed, and dimensional comparisons were made for each meniscal model with baseline (0°-unloaded model). The morphologic changes of the meniscal-anterior horn (AH), body (BD), and posterior horn (PH) regions were expressed as mean positive and negative deviations. The displacements were further investigated, and the meniscal extrusions of different subregions were measured. The morphologic changing patterns of human meniscus under loading and flexions were presented using 3D chromatic maps. The bilateral menisci were generally shifting laterally and posteriorly in most flexion angles and were changing medially and anteriorly under fully extended knee loading conditions. The mean deviations were more significant with loading at 0° of knee flexion, while the PH region in the lateral side changed further posteriorly with loading in 30° flexion. Most of the differences were not significant in other flexion angles between loading conditions. The extrusion of meniscus’s medial body was greater in full extension compared to any other flexing angles. Mechanical loading can significantly deform the menisci in knee extension; however, this effect is limited during knee flexion. Current study can be used as a reference for the evaluations of the integrity in meniscal functions.
format	article
author	Tong Liu Xianyue Shen Qingming Ji Jianlin Xiao Jianlin Zuo Zhongli Gao
author_facet	Tong Liu Xianyue Shen Qingming Ji Jianlin Xiao Jianlin Zuo Zhongli Gao
author_sort	Tong Liu
title	The MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions
title_short	The MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions
title_full	The MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions
title_fullStr	The MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions
title_full_unstemmed	The MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions
title_sort	mri-based 3d morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa8be69e0f1f438dbaaf1746697dc155
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The MRI-based 3D morphologic changes of knee meniscus under knee weight-bearing and early flexion conditions

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