Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.

Chronic immune activation (IA) is considered as the driving force of CD4(+) T cell depletion and AIDS. Fundamental clues in the mechanisms that regulate IA could lie in natural hosts of SIV, such as African green monkeys (AGMs). Here we investigated the role of innate immune cells and IFN-α in the c...

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Autores principales:	Béatrice Jacquelin, Gaël Petitjean, Désirée Kunkel, Anne-Sophie Liovat, Simon P Jochems, Kenneth A Rogers, Mickaël J Ploquin, Yoann Madec, Françoise Barré-Sinoussi, Nathalie Dereuddre-Bosquet, Pierre Lebon, Roger Le Grand, François Villinger, Michaela Müller-Trutwin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fa8de60be3134b30aff1786ab24f2a00
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spelling	oai:doaj.org-article:fa8de60be3134b30aff1786ab24f2a002021-11-25T05:46:19ZInnate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.1553-73661553-737410.1371/journal.ppat.1004241https://doaj.org/article/fa8de60be3134b30aff1786ab24f2a002014-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24991927/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Chronic immune activation (IA) is considered as the driving force of CD4(+) T cell depletion and AIDS. Fundamental clues in the mechanisms that regulate IA could lie in natural hosts of SIV, such as African green monkeys (AGMs). Here we investigated the role of innate immune cells and IFN-α in the control of IA in AGMs. AGMs displayed significant NK cell activation upon SIVagm infection, which was correlated with the levels of IFN-α. Moreover, we detected cytotoxic NK cells in lymph nodes during the early acute phase of SIVagm infection. Both plasmacytoid and myeloid dendritic cell (pDC and mDC) homing receptors were increased, but the maturation of mDCs, in particular of CD16+ mDCs, was more important than that of pDCs. Monitoring of 15 cytokines showed that those, which are known to be increased early in HIV-1/SIVmac pathogenic infections, such as IL-15, IFN-α, MCP-1 and CXCL10/IP-10, were significantly increased in AGMs as well. In contrast, cytokines generally induced in the later stage of acute pathogenic infection, such as IL-6, IL-18 and TNF-α, were less or not increased, suggesting an early control of IA. We then treated AGMs daily with high doses of IFN-α from day 9 to 24 post-infection. No impact was observed on the activation or maturation profiles of mDCs, pDCs and NK cells. There was also no major difference in T cell activation or interferon-stimulated gene (ISG) expression profiles and no sign of disease progression. Thus, even after administration of high levels of IFN-α during acute infection, AGMs were still able to control IA, showing that IA control is independent of IFN-α levels. This suggests that the sustained ISG expression and IA in HIV/SIVmac infections involves non-IFN-α products.Béatrice JacquelinGaël PetitjeanDésirée KunkelAnne-Sophie LiovatSimon P JochemsKenneth A RogersMickaël J PloquinYoann MadecFrançoise Barré-SinoussiNathalie Dereuddre-BosquetPierre LebonRoger Le GrandFrançois VillingerMichaela Müller-TrutwinPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 10, Iss 7, p e1004241 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Béatrice Jacquelin Gaël Petitjean Désirée Kunkel Anne-Sophie Liovat Simon P Jochems Kenneth A Rogers Mickaël J Ploquin Yoann Madec Françoise Barré-Sinoussi Nathalie Dereuddre-Bosquet Pierre Lebon Roger Le Grand François Villinger Michaela Müller-Trutwin Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.
description	Chronic immune activation (IA) is considered as the driving force of CD4(+) T cell depletion and AIDS. Fundamental clues in the mechanisms that regulate IA could lie in natural hosts of SIV, such as African green monkeys (AGMs). Here we investigated the role of innate immune cells and IFN-α in the control of IA in AGMs. AGMs displayed significant NK cell activation upon SIVagm infection, which was correlated with the levels of IFN-α. Moreover, we detected cytotoxic NK cells in lymph nodes during the early acute phase of SIVagm infection. Both plasmacytoid and myeloid dendritic cell (pDC and mDC) homing receptors were increased, but the maturation of mDCs, in particular of CD16+ mDCs, was more important than that of pDCs. Monitoring of 15 cytokines showed that those, which are known to be increased early in HIV-1/SIVmac pathogenic infections, such as IL-15, IFN-α, MCP-1 and CXCL10/IP-10, were significantly increased in AGMs as well. In contrast, cytokines generally induced in the later stage of acute pathogenic infection, such as IL-6, IL-18 and TNF-α, were less or not increased, suggesting an early control of IA. We then treated AGMs daily with high doses of IFN-α from day 9 to 24 post-infection. No impact was observed on the activation or maturation profiles of mDCs, pDCs and NK cells. There was also no major difference in T cell activation or interferon-stimulated gene (ISG) expression profiles and no sign of disease progression. Thus, even after administration of high levels of IFN-α during acute infection, AGMs were still able to control IA, showing that IA control is independent of IFN-α levels. This suggests that the sustained ISG expression and IA in HIV/SIVmac infections involves non-IFN-α products.
format	article
author	Béatrice Jacquelin Gaël Petitjean Désirée Kunkel Anne-Sophie Liovat Simon P Jochems Kenneth A Rogers Mickaël J Ploquin Yoann Madec Françoise Barré-Sinoussi Nathalie Dereuddre-Bosquet Pierre Lebon Roger Le Grand François Villinger Michaela Müller-Trutwin
author_facet	Béatrice Jacquelin Gaël Petitjean Désirée Kunkel Anne-Sophie Liovat Simon P Jochems Kenneth A Rogers Mickaël J Ploquin Yoann Madec Françoise Barré-Sinoussi Nathalie Dereuddre-Bosquet Pierre Lebon Roger Le Grand François Villinger Michaela Müller-Trutwin
author_sort	Béatrice Jacquelin
title	Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.
title_short	Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.
title_full	Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.
title_fullStr	Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.
title_full_unstemmed	Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.
title_sort	innate immune responses and rapid control of inflammation in african green monkeys treated or not with interferon-alpha during primary sivagm infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fa8de60be3134b30aff1786ab24f2a00
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Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.

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