SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study

Endothelial inflammation and vascular damage are essential risk factors contributing to hypertension. Suppressor of cytokine signaling 3 (SOCS3) is involved in the regulation of multiple inflammatory pathways. A large number of studies have shown that the anti-inflammatory effect of SOCS3 in hyperte...

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Autores principales:	Dabin Kuang, Lichen Dong, Lingyun Liu, Meiling Zuo, Yuanlin Xie, Taoming Li, Zhousheng Yang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/fa918ac7d8cd4d2ca29b326c25040a81
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spelling	oai:doaj.org-article:fa918ac7d8cd4d2ca29b326c25040a812021-11-29T00:55:27ZSOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study2314-614110.1155/2021/8445461https://doaj.org/article/fa918ac7d8cd4d2ca29b326c25040a812021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8445461https://doaj.org/toc/2314-6141Endothelial inflammation and vascular damage are essential risk factors contributing to hypertension. Suppressor of cytokine signaling 3 (SOCS3) is involved in the regulation of multiple inflammatory pathways. A large number of studies have shown that the anti-inflammatory effect of SOCS3 in hypertension, obesity, and allergic reactions has brought more insights into the inhibition of inflammation. Therefore, we selected a tagSNP of SOCS3 (rs8064821) to investigate whether they are contributing to the risk of hypertension in the Chinese population. In total, 532 patients with hypertension and 569 healthy controls were enrolled for two central of China. SOCS3 rs8064821 C>A polymorphism was genotyped using TaqMan assay. SOCS3 rs8064821 CA genotype was associated with an increased risk of hypertension (OR=1.821, 95%CI=1.276-2.600, P=0.001). Rs8064821 A allele was associated with higher SOCS3 mRNA level in PBMCs from healthy donors. SOCS3 rs8064821 C>A polymorphism may contribute to the risk of hypertension in the Chinese population by regulating the expression of SOCS3.Dabin KuangLichen DongLingyun LiuMeiling ZuoYuanlin XieTaoming LiZhousheng YangHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Dabin Kuang Lichen Dong Lingyun Liu Meiling Zuo Yuanlin Xie Taoming Li Zhousheng Yang SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study
description	Endothelial inflammation and vascular damage are essential risk factors contributing to hypertension. Suppressor of cytokine signaling 3 (SOCS3) is involved in the regulation of multiple inflammatory pathways. A large number of studies have shown that the anti-inflammatory effect of SOCS3 in hypertension, obesity, and allergic reactions has brought more insights into the inhibition of inflammation. Therefore, we selected a tagSNP of SOCS3 (rs8064821) to investigate whether they are contributing to the risk of hypertension in the Chinese population. In total, 532 patients with hypertension and 569 healthy controls were enrolled for two central of China. SOCS3 rs8064821 C>A polymorphism was genotyped using TaqMan assay. SOCS3 rs8064821 CA genotype was associated with an increased risk of hypertension (OR=1.821, 95%CI=1.276-2.600, P=0.001). Rs8064821 A allele was associated with higher SOCS3 mRNA level in PBMCs from healthy donors. SOCS3 rs8064821 C>A polymorphism may contribute to the risk of hypertension in the Chinese population by regulating the expression of SOCS3.
format	article
author	Dabin Kuang Lichen Dong Lingyun Liu Meiling Zuo Yuanlin Xie Taoming Li Zhousheng Yang
author_facet	Dabin Kuang Lichen Dong Lingyun Liu Meiling Zuo Yuanlin Xie Taoming Li Zhousheng Yang
author_sort	Dabin Kuang
title	SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study
title_short	SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study
title_full	SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study
title_fullStr	SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study
title_full_unstemmed	SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study
title_sort	socs3 gene polymorphism and hypertension susceptibility in chinese population: a two-center case-control study
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/fa918ac7d8cd4d2ca29b326c25040a81
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SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study

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