Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.
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Nature Portfolio
2020
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oai:doaj.org-article:fa92c2f7fbcd485fb13c6e8b461e9fce2021-12-02T16:32:09ZTumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients10.1038/s41467-020-17046-22041-1723https://doaj.org/article/fa92c2f7fbcd485fb13c6e8b461e9fce2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17046-2https://doaj.org/toc/2041-1723Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.Nicolas Gonzalo NúñezJimena Tosello BoariRodrigo Nalio RamosWilfrid RicherNicolas CagnardCyrill Dimitri AnderfuhrenLeticia Laura NiborskiJeremy BigotDidier MeseurePhilippe De La RochereMaud MilderSophie VielDelphine LoiratLouis PérolAnne Vincent-SalomonXavier Sastre-GarauBecher BurkhardChristine SedlikOlivier LantzSebastian AmigorenaEliane PiaggioNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nicolas Gonzalo Núñez Jimena Tosello Boari Rodrigo Nalio Ramos Wilfrid Richer Nicolas Cagnard Cyrill Dimitri Anderfuhren Leticia Laura Niborski Jeremy Bigot Didier Meseure Philippe De La Rochere Maud Milder Sophie Viel Delphine Loirat Louis Pérol Anne Vincent-Salomon Xavier Sastre-Garau Becher Burkhard Christine Sedlik Olivier Lantz Sebastian Amigorena Eliane Piaggio Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients |
| description |
Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors. |
| format |
article |
| author |
Nicolas Gonzalo Núñez Jimena Tosello Boari Rodrigo Nalio Ramos Wilfrid Richer Nicolas Cagnard Cyrill Dimitri Anderfuhren Leticia Laura Niborski Jeremy Bigot Didier Meseure Philippe De La Rochere Maud Milder Sophie Viel Delphine Loirat Louis Pérol Anne Vincent-Salomon Xavier Sastre-Garau Becher Burkhard Christine Sedlik Olivier Lantz Sebastian Amigorena Eliane Piaggio |
| author_facet |
Nicolas Gonzalo Núñez Jimena Tosello Boari Rodrigo Nalio Ramos Wilfrid Richer Nicolas Cagnard Cyrill Dimitri Anderfuhren Leticia Laura Niborski Jeremy Bigot Didier Meseure Philippe De La Rochere Maud Milder Sophie Viel Delphine Loirat Louis Pérol Anne Vincent-Salomon Xavier Sastre-Garau Becher Burkhard Christine Sedlik Olivier Lantz Sebastian Amigorena Eliane Piaggio |
| author_sort |
Nicolas Gonzalo Núñez |
| title |
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients |
| title_short |
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients |
| title_full |
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients |
| title_fullStr |
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients |
| title_full_unstemmed |
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients |
| title_sort |
tumor invasion in draining lymph nodes is associated with treg accumulation in breast cancer patients |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/fa92c2f7fbcd485fb13c6e8b461e9fce |
| work_keys_str_mv |
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