TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease

A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into...

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Autores principales:	Christian B. Lindstad, Alisa E. Dewan, Jorunn Stamnaes, Ludvig M. Sollid, M. Fleur du Pré
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa939a27166143e9a3304aef314a1786
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spelling	oai:doaj.org-article:fa939a27166143e9a3304aef314a17862021-11-11T07:14:46ZTG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease1932-6203https://doaj.org/article/fa939a27166143e9a3304aef314a17862021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565743/?tool=EBIhttps://doaj.org/toc/1932-6203A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into antibody-producing plasma cells. We have here studied the collaboration between DGP- and TG2-specific B cells with gluten-specific CD4+ T cells using transgenic mice expressing celiac patient-derived T-cell and B-cell receptors, as well as between B-cell transfectants and patient-derived gluten-specific T-cell clones. We show that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells and allow both types of B cells to receive help from gluten-specific T cells of many different specificities.Christian B. LindstadAlisa E. DewanJorunn StamnaesLudvig M. SollidM. Fleur du PréPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian B. Lindstad Alisa E. Dewan Jorunn Stamnaes Ludvig M. Sollid M. Fleur du Pré TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
description	A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into antibody-producing plasma cells. We have here studied the collaboration between DGP- and TG2-specific B cells with gluten-specific CD4+ T cells using transgenic mice expressing celiac patient-derived T-cell and B-cell receptors, as well as between B-cell transfectants and patient-derived gluten-specific T-cell clones. We show that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells and allow both types of B cells to receive help from gluten-specific T cells of many different specificities.
format	article
author	Christian B. Lindstad Alisa E. Dewan Jorunn Stamnaes Ludvig M. Sollid M. Fleur du Pré
author_facet	Christian B. Lindstad Alisa E. Dewan Jorunn Stamnaes Ludvig M. Sollid M. Fleur du Pré
author_sort	Christian B. Lindstad
title	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
title_short	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
title_full	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
title_fullStr	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
title_full_unstemmed	TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
title_sort	tg2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific b cells in celiac disease
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fa939a27166143e9a3304aef314a1786
work_keys_str_mv	AT christianblindstad tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease AT alisaedewan tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease AT jorunnstamnaes tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease AT ludvigmsollid tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease AT mfleurdupre tg2glutencomplexesasantigensforglutenspecificandtransglutaminase2specificbcellsinceliacdisease
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TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease

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