Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but also serves as a virulence regulatory hub in species of pathogenic fungi that rely on secretory pathway homeostasis for pathogenicity. This study demonstrates that the gene encoding the ER-localize...

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Autores principales:	José P. Guirao-Abad, Martin Weichert, Ginés Luengo-Gil, Sarah Sze Wah Wong, Vishukumar Aimanianda, Christina Grisham, Nikita Malev, Shivani Reddy, Laura Woollett, David S. Askew
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/fa945191fa4942a0a1c0c0808abce8b6
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spelling	oai:doaj.org-article:fa945191fa4942a0a1c0c0808abce8b62021-11-03T21:52:36ZPleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus2150-751110.1128/mBio.02735-21https://doaj.org/article/fa945191fa4942a0a1c0c0808abce8b62021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02735-21https://doaj.org/toc/2150-7511 The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but also serves as a virulence regulatory hub in species of pathogenic fungi that rely on secretory pathway homeostasis for pathogenicity. This study demonstrates that the gene encoding the ER-localized P5-type ATPase SpfA is a downstream target of the UPR in the pathogenic mold A. fumigatusA. fumigatusJosé P. Guirao-AbadMartin WeichertGinés Luengo-GilSarah Sze Wah WongVishukumar AimaniandaChristina GrishamNikita MalevShivani ReddyLaura WoollettDavid S. AskewAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 José P. Guirao-Abad Martin Weichert Ginés Luengo-Gil Sarah Sze Wah Wong Vishukumar Aimanianda Christina Grisham Nikita Malev Shivani Reddy Laura Woollett David S. Askew Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus
description	The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but also serves as a virulence regulatory hub in species of pathogenic fungi that rely on secretory pathway homeostasis for pathogenicity. This study demonstrates that the gene encoding the ER-localized P5-type ATPase SpfA is a downstream target of the UPR in the pathogenic mold A. fumigatusA. fumigatus
format	article
author	José P. Guirao-Abad Martin Weichert Ginés Luengo-Gil Sarah Sze Wah Wong Vishukumar Aimanianda Christina Grisham Nikita Malev Shivani Reddy Laura Woollett David S. Askew
author_facet	José P. Guirao-Abad Martin Weichert Ginés Luengo-Gil Sarah Sze Wah Wong Vishukumar Aimanianda Christina Grisham Nikita Malev Shivani Reddy Laura Woollett David S. Askew
author_sort	José P. Guirao-Abad
title	Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus
title_short	Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus
title_full	Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus
title_fullStr	Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus
title_full_unstemmed	Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus
title_sort	pleiotropic effects of the p5-type atpase spfa on stress response networks contribute to virulence in the pathogenic mold aspergillus fumigatus
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/fa945191fa4942a0a1c0c0808abce8b6
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Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

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