Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but also serves as a virulence regulatory hub in species of pathogenic fungi that rely on secretory pathway homeostasis for pathogenicity. This study demonstrates that the gene encoding the ER-localize...

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Main Authors: José P. Guirao-Abad, Martin Weichert, Ginés Luengo-Gil, Sarah Sze Wah Wong, Vishukumar Aimanianda, Christina Grisham, Nikita Malev, Shivani Reddy, Laura Woollett, David S. Askew
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/fa945191fa4942a0a1c0c0808abce8b6
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