IMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA

Abstract. A study of cell and humoral immune indices was carried out in forty-five pre-treated patients with multiple myeloma. Imbalance in T:B lymphocyte ratio was revealed, due to increased CD3+ cells and decreased CD20+ cell levels. Accordingly, lowered levels of HLA-DR-lymphocytes, high CD8 cell...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	E. A. Senkina, G. A. Zaitseva, T. P. Zagoskina, T. G. Gradoboeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	multiple myeloma immune indices Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/fa945d63f1f84fd481616c5452e58a71
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa945d63f1f84fd481616c5452e58a71
record_format	dspace
spelling	oai:doaj.org-article:fa945d63f1f84fd481616c5452e58a712021-11-18T08:03:40ZIMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA1563-06252313-741X10.15789/1563-0625-2009-6-571-576https://doaj.org/article/fa945d63f1f84fd481616c5452e58a712014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/371https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A study of cell and humoral immune indices was carried out in forty-five pre-treated patients with multiple myeloma. Imbalance in T:B lymphocyte ratio was revealed, due to increased CD3+ cells and decreased CD20+ cell levels. Accordingly, lowered levels of HLA-DR-lymphocytes, high CD8 cell scores, low percentages of phagocytizing neutrophils, decreased IgM and complement titers, increased serum lysozyme and β-lysine activities were observed. Immune disorders in the patients with II and III stage disease were much more frequent, as compared to stage I, and they depended on immune variant of myeloma. Minimal immune defects were noted in cases with Bence Jones variant. High-dose chemotherapy resulted into more expressed immune disorders, mainly, altered T-cell immunity. These data are indicative for a necessity of a regular immunological monitoring, aiming for administration of immunocorrective therapy.E. A. SenkinaG. A. ZaitsevaT. P. ZagoskinaT. G. GradoboevaSPb RAACIarticlemultiple myelomaimmune indicesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 571-576 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	multiple myeloma immune indices Immunologic diseases. Allergy RC581-607
spellingShingle	multiple myeloma immune indices Immunologic diseases. Allergy RC581-607 E. A. Senkina G. A. Zaitseva T. P. Zagoskina T. G. Gradoboeva IMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA
description	Abstract. A study of cell and humoral immune indices was carried out in forty-five pre-treated patients with multiple myeloma. Imbalance in T:B lymphocyte ratio was revealed, due to increased CD3+ cells and decreased CD20+ cell levels. Accordingly, lowered levels of HLA-DR-lymphocytes, high CD8 cell scores, low percentages of phagocytizing neutrophils, decreased IgM and complement titers, increased serum lysozyme and β-lysine activities were observed. Immune disorders in the patients with II and III stage disease were much more frequent, as compared to stage I, and they depended on immune variant of myeloma. Minimal immune defects were noted in cases with Bence Jones variant. High-dose chemotherapy resulted into more expressed immune disorders, mainly, altered T-cell immunity. These data are indicative for a necessity of a regular immunological monitoring, aiming for administration of immunocorrective therapy.
format	article
author	E. A. Senkina G. A. Zaitseva T. P. Zagoskina T. G. Gradoboeva
author_facet	E. A. Senkina G. A. Zaitseva T. P. Zagoskina T. G. Gradoboeva
author_sort	E. A. Senkina
title	IMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA
title_short	IMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA
title_full	IMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA
title_fullStr	IMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA
title_full_unstemmed	IMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA
title_sort	immune disturbances in patients with multiple myeloma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/fa945d63f1f84fd481616c5452e58a71
work_keys_str_mv	AT easenkina immunedisturbancesinpatientswithmultiplemyeloma AT gazaitseva immunedisturbancesinpatientswithmultiplemyeloma AT tpzagoskina immunedisturbancesinpatientswithmultiplemyeloma AT tggradoboeva immunedisturbancesinpatientswithmultiplemyeloma
_version_	1718422519873011712

IMMUNE DISTURBANCES IN PATIENTS WITH MULTIPLE MYELOMA

Ejemplares similares