Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study

Ankur K Shrivastava, Swatishree Nayak, Mary Anto Department of Ophthalmology, All India Institute of Medical Sciences, Raipur, IndiaCorrespondence: Ankur K Shrivastava Flat No. 603, Type 5A, AIIMS Residential Complex, Kabir Nagar, Raipur, Chhattisgarh, 492099, IndiaEmail shrivastavadrankur@gmail.com...

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Autores principales:	Shrivastava AK, Nayak S, Anto M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	topical nepafenac topical flurbiprofen intra-operative mydriasis phacoemulsification Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fa9460c882a047b0935fa99a5d279031
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spelling	oai:doaj.org-article:fa9460c882a047b0935fa99a5d2790312021-12-02T17:09:43ZEfficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study1177-5483https://doaj.org/article/fa9460c882a047b0935fa99a5d2790312021-03-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-nepafenac-versus-flurbiprofen-in-maintaining-intraoperativ-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ankur K Shrivastava, Swatishree Nayak, Mary Anto Department of Ophthalmology, All India Institute of Medical Sciences, Raipur, IndiaCorrespondence: Ankur K Shrivastava Flat No. 603, Type 5A, AIIMS Residential Complex, Kabir Nagar, Raipur, Chhattisgarh, 492099, IndiaEmail shrivastavadrankur@gmail.comPurpose: To compare the efficacy of topical nepafenac (0.1%) with flurbiprofen (0.03%) in maintaining intra-operative mydriasis during phacoemulsification surgery.Patients and Methods: This study comprised of 160 patients, who were divided into two arms of 80 each (arms A and B) after randomisation. Pre-operatively, all patients received one drop of tropicamide 0.8% and phenylephrine 5% (combination), 4 times, at an interval of 15 minutes on the day of surgery. Thereafter, Nepafenac drop in arm A/Flurbiprofen drop in arm B was administered 4 times, at an interval of 15 minutes keeping a gap of 10 minutes between tropicamide-phenylephrine and any of the experimental drugs. Phacoemulsification was performed one hour after the administration of last drop. Both vertical and horizontal pupillary diameter were measured at three steps; immediately before the surgical incision (baseline), at the end of emulsification of nucleus (before irrigation and aspiration) and at the end of surgery (after stromal hydration).Results: The difference in pupillary diameter between two groups, was statistically insignificant for vertical diameter (P = 0.08) and horizontal diameter (P = 0.28) at the start of surgery. On the other hand, pupillary diameter difference was statistically significant after emulsification of nucleus and at the end of surgery as well when both vertical (P < 0.05) and horizontal diameter (P < 0.05) were considered. The total reduction in pupillary diameter (both vertically and horizontally) was significantly less in the Nepafenac as compared to Flurbiprofen group (P < 0.05). Analysis of mean cumulative dissipated energy did not document any appreciable difference between the two groups. Phacoemulsification time analysis yielded statistically significant results (P = 0.004) between the Nepafenac and Flurbiprofen group.Conclusion: In the present study, topical Nepafenac (0.1%) proved to be more efficacious in maintaining intra-operative mydriasis during phacoemulsification surgery as compared to topical Flurbiprofen (0.03%).Keywords: topical nepafenac, topical flurbiprofen, intra-operative mydriasis, phacoemulsificationShrivastava AKNayak SAnto MDove Medical Pressarticletopical nepafenactopical flurbiprofenintra-operative mydriasisphacoemulsificationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1085-1093 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	topical nepafenac topical flurbiprofen intra-operative mydriasis phacoemulsification Ophthalmology RE1-994
spellingShingle	topical nepafenac topical flurbiprofen intra-operative mydriasis phacoemulsification Ophthalmology RE1-994 Shrivastava AK Nayak S Anto M Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study
description	Ankur K Shrivastava, Swatishree Nayak, Mary Anto Department of Ophthalmology, All India Institute of Medical Sciences, Raipur, IndiaCorrespondence: Ankur K Shrivastava Flat No. 603, Type 5A, AIIMS Residential Complex, Kabir Nagar, Raipur, Chhattisgarh, 492099, IndiaEmail shrivastavadrankur@gmail.comPurpose: To compare the efficacy of topical nepafenac (0.1%) with flurbiprofen (0.03%) in maintaining intra-operative mydriasis during phacoemulsification surgery.Patients and Methods: This study comprised of 160 patients, who were divided into two arms of 80 each (arms A and B) after randomisation. Pre-operatively, all patients received one drop of tropicamide 0.8% and phenylephrine 5% (combination), 4 times, at an interval of 15 minutes on the day of surgery. Thereafter, Nepafenac drop in arm A/Flurbiprofen drop in arm B was administered 4 times, at an interval of 15 minutes keeping a gap of 10 minutes between tropicamide-phenylephrine and any of the experimental drugs. Phacoemulsification was performed one hour after the administration of last drop. Both vertical and horizontal pupillary diameter were measured at three steps; immediately before the surgical incision (baseline), at the end of emulsification of nucleus (before irrigation and aspiration) and at the end of surgery (after stromal hydration).Results: The difference in pupillary diameter between two groups, was statistically insignificant for vertical diameter (P = 0.08) and horizontal diameter (P = 0.28) at the start of surgery. On the other hand, pupillary diameter difference was statistically significant after emulsification of nucleus and at the end of surgery as well when both vertical (P < 0.05) and horizontal diameter (P < 0.05) were considered. The total reduction in pupillary diameter (both vertically and horizontally) was significantly less in the Nepafenac as compared to Flurbiprofen group (P < 0.05). Analysis of mean cumulative dissipated energy did not document any appreciable difference between the two groups. Phacoemulsification time analysis yielded statistically significant results (P = 0.004) between the Nepafenac and Flurbiprofen group.Conclusion: In the present study, topical Nepafenac (0.1%) proved to be more efficacious in maintaining intra-operative mydriasis during phacoemulsification surgery as compared to topical Flurbiprofen (0.03%).Keywords: topical nepafenac, topical flurbiprofen, intra-operative mydriasis, phacoemulsification
format	article
author	Shrivastava AK Nayak S Anto M
author_facet	Shrivastava AK Nayak S Anto M
author_sort	Shrivastava AK
title	Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study
title_short	Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study
title_full	Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study
title_fullStr	Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study
title_full_unstemmed	Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study
title_sort	efficacy of nepafenac versus flurbiprofen in maintaining intraoperative mydriasis during phacoemulsification: a comparative study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/fa9460c882a047b0935fa99a5d279031
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Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study

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