Novel gene function revealed by mouse mutagenesis screens for models of age-related disease
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome se...
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| Lenguaje: | EN |
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/fa97ab87303c498f824c8286a0325379 |
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oai:doaj.org-article:fa97ab87303c498f824c8286a03253792021-12-02T17:31:18ZNovel gene function revealed by mouse mutagenesis screens for models of age-related disease10.1038/ncomms124442041-1723https://doaj.org/article/fa97ab87303c498f824c8286a03253792016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12444https://doaj.org/toc/2041-1723Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome sequencing.Paul K. PotterMichael R. BowlPrashanthini JeyarajanLaura WisbyAndrew BleaseMichelle E. GoldsworthyMichelle M. SimonSimon GreenawayVincent MichelAlun BarnardCarlos AguilarThomas AgnewGareth BanksAndrew BlakeLauren ChessumJoanne DorningSara FalconeLaurence GooseyShelley HarrisAndy HaynesInes HeiseRosie HillierTertius HoughAngela HoslinMarie HutchisonRuairidh KingSaumya KumarHeena V. LadGemma LawRobert E. MacLarenSusan MorseThomas NicolAndrew ParkerKaren PickfordSiddharth SethiBecky StarbuckFemke StelmaMichael CheesemanSally H. CrossRussell G. FosterIan J. JacksonStuart N. PeirsonRajesh V. ThakkerTonia VincentCheryl ScudamoreSara WellsAziz El-AmraouiChristine PetitAbraham Acevedo-ArozenaPatrick M. NolanRoger CoxAnne-Marie MallonSteve D. M. BrownNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Paul K. Potter Michael R. Bowl Prashanthini Jeyarajan Laura Wisby Andrew Blease Michelle E. Goldsworthy Michelle M. Simon Simon Greenaway Vincent Michel Alun Barnard Carlos Aguilar Thomas Agnew Gareth Banks Andrew Blake Lauren Chessum Joanne Dorning Sara Falcone Laurence Goosey Shelley Harris Andy Haynes Ines Heise Rosie Hillier Tertius Hough Angela Hoslin Marie Hutchison Ruairidh King Saumya Kumar Heena V. Lad Gemma Law Robert E. MacLaren Susan Morse Thomas Nicol Andrew Parker Karen Pickford Siddharth Sethi Becky Starbuck Femke Stelma Michael Cheeseman Sally H. Cross Russell G. Foster Ian J. Jackson Stuart N. Peirson Rajesh V. Thakker Tonia Vincent Cheryl Scudamore Sara Wells Aziz El-Amraoui Christine Petit Abraham Acevedo-Arozena Patrick M. Nolan Roger Cox Anne-Marie Mallon Steve D. M. Brown Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| description |
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome sequencing. |
| format |
article |
| author |
Paul K. Potter Michael R. Bowl Prashanthini Jeyarajan Laura Wisby Andrew Blease Michelle E. Goldsworthy Michelle M. Simon Simon Greenaway Vincent Michel Alun Barnard Carlos Aguilar Thomas Agnew Gareth Banks Andrew Blake Lauren Chessum Joanne Dorning Sara Falcone Laurence Goosey Shelley Harris Andy Haynes Ines Heise Rosie Hillier Tertius Hough Angela Hoslin Marie Hutchison Ruairidh King Saumya Kumar Heena V. Lad Gemma Law Robert E. MacLaren Susan Morse Thomas Nicol Andrew Parker Karen Pickford Siddharth Sethi Becky Starbuck Femke Stelma Michael Cheeseman Sally H. Cross Russell G. Foster Ian J. Jackson Stuart N. Peirson Rajesh V. Thakker Tonia Vincent Cheryl Scudamore Sara Wells Aziz El-Amraoui Christine Petit Abraham Acevedo-Arozena Patrick M. Nolan Roger Cox Anne-Marie Mallon Steve D. M. Brown |
| author_facet |
Paul K. Potter Michael R. Bowl Prashanthini Jeyarajan Laura Wisby Andrew Blease Michelle E. Goldsworthy Michelle M. Simon Simon Greenaway Vincent Michel Alun Barnard Carlos Aguilar Thomas Agnew Gareth Banks Andrew Blake Lauren Chessum Joanne Dorning Sara Falcone Laurence Goosey Shelley Harris Andy Haynes Ines Heise Rosie Hillier Tertius Hough Angela Hoslin Marie Hutchison Ruairidh King Saumya Kumar Heena V. Lad Gemma Law Robert E. MacLaren Susan Morse Thomas Nicol Andrew Parker Karen Pickford Siddharth Sethi Becky Starbuck Femke Stelma Michael Cheeseman Sally H. Cross Russell G. Foster Ian J. Jackson Stuart N. Peirson Rajesh V. Thakker Tonia Vincent Cheryl Scudamore Sara Wells Aziz El-Amraoui Christine Petit Abraham Acevedo-Arozena Patrick M. Nolan Roger Cox Anne-Marie Mallon Steve D. M. Brown |
| author_sort |
Paul K. Potter |
| title |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_short |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_full |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_fullStr |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_full_unstemmed |
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| title_sort |
novel gene function revealed by mouse mutagenesis screens for models of age-related disease |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/fa97ab87303c498f824c8286a0325379 |
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