Effects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.

<h4>Background & aims</h4>Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jordi Mayneris-Perxachs, Aleix Sala-Vila, Maribel Chisaguano, Ana I Castellote, Ramón Estruch, María Isabel Covas, Montserrat Fitó, Jordi Salas-Salvadó, Miguel A Martínez-González, Rosa Lamuela-Raventós, Emilio Ros, M Carmen López-Sabater, PREDIMED Study Investigators
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
R
Q
Acceso en línea:https://doaj.org/article/fa993d5cc5604dc49ddae5bce554aa45
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:fa993d5cc5604dc49ddae5bce554aa45
record_format dspace
spelling oai:doaj.org-article:fa993d5cc5604dc49ddae5bce554aa452021-11-18T08:27:10ZEffects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.1932-620310.1371/journal.pone.0085202https://doaj.org/article/fa993d5cc5604dc49ddae5bce554aa452014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651160/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background & aims</h4>Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention.<h4>Methods</h4>A total of 424 subjects were randomly selected from the PREDIMED randomized dietary trial after completing a 1-year intervention program. Participants aged 55 to 80 years and at high risk of cardiovascular disease were randomly assigned to three dietary interventions: Mediterranean diet supplemented with virgin olive oil or nuts, or a low-fat diet.<h4>Results</h4>After 1 year of intervention participants in the virgin olive oil group showed significantly increased plasma concentrations of palmitic and oleic acids, but reduced proportions of margaric, stearic, and linoleic acids. In turn, subjects in the nut group showed significantly increased levels of palmitic, linoleic, and α-linolenic acids, but reduced proportions of myristic, margaric, palmitoleic, and dihommo-γ-linoleic acids. Increases in the biomarkers of foods supplied to the Mediterranean diet groups, i.e., oleic and α-linolenic acids, were beneficially associated with the incidence, reversion and prevalence of MetS. No weight changes were observed among participants.<h4>Conclusions</h4>The nut and olive oil diets induced a fatty acid composition that has been shown to be beneficial in the face of MetS. Therefore, a Mediterranean diet rich in fats of vegetable origin may be a useful tool for the management of MetS without the need for concerns over weight gain due to its high fat content.<h4>Trial registration</h4>Controlled-Trials.com ISRCTN35739639.Jordi Mayneris-PerxachsAleix Sala-VilaMaribel ChisaguanoAna I CastelloteRamón EstruchMaría Isabel CovasMontserrat FitóJordi Salas-SalvadóMiguel A Martínez-GonzálezRosa Lamuela-RaventósEmilio RosM Carmen López-SabaterPREDIMED Study InvestigatorsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e85202 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jordi Mayneris-Perxachs
Aleix Sala-Vila
Maribel Chisaguano
Ana I Castellote
Ramón Estruch
María Isabel Covas
Montserrat Fitó
Jordi Salas-Salvadó
Miguel A Martínez-González
Rosa Lamuela-Raventós
Emilio Ros
M Carmen López-Sabater
PREDIMED Study Investigators
Effects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.
description <h4>Background & aims</h4>Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention.<h4>Methods</h4>A total of 424 subjects were randomly selected from the PREDIMED randomized dietary trial after completing a 1-year intervention program. Participants aged 55 to 80 years and at high risk of cardiovascular disease were randomly assigned to three dietary interventions: Mediterranean diet supplemented with virgin olive oil or nuts, or a low-fat diet.<h4>Results</h4>After 1 year of intervention participants in the virgin olive oil group showed significantly increased plasma concentrations of palmitic and oleic acids, but reduced proportions of margaric, stearic, and linoleic acids. In turn, subjects in the nut group showed significantly increased levels of palmitic, linoleic, and α-linolenic acids, but reduced proportions of myristic, margaric, palmitoleic, and dihommo-γ-linoleic acids. Increases in the biomarkers of foods supplied to the Mediterranean diet groups, i.e., oleic and α-linolenic acids, were beneficially associated with the incidence, reversion and prevalence of MetS. No weight changes were observed among participants.<h4>Conclusions</h4>The nut and olive oil diets induced a fatty acid composition that has been shown to be beneficial in the face of MetS. Therefore, a Mediterranean diet rich in fats of vegetable origin may be a useful tool for the management of MetS without the need for concerns over weight gain due to its high fat content.<h4>Trial registration</h4>Controlled-Trials.com ISRCTN35739639.
format article
author Jordi Mayneris-Perxachs
Aleix Sala-Vila
Maribel Chisaguano
Ana I Castellote
Ramón Estruch
María Isabel Covas
Montserrat Fitó
Jordi Salas-Salvadó
Miguel A Martínez-González
Rosa Lamuela-Raventós
Emilio Ros
M Carmen López-Sabater
PREDIMED Study Investigators
author_facet Jordi Mayneris-Perxachs
Aleix Sala-Vila
Maribel Chisaguano
Ana I Castellote
Ramón Estruch
María Isabel Covas
Montserrat Fitó
Jordi Salas-Salvadó
Miguel A Martínez-González
Rosa Lamuela-Raventós
Emilio Ros
M Carmen López-Sabater
PREDIMED Study Investigators
author_sort Jordi Mayneris-Perxachs
title Effects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.
title_short Effects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.
title_full Effects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.
title_fullStr Effects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.
title_full_unstemmed Effects of 1-year intervention with a Mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.
title_sort effects of 1-year intervention with a mediterranean diet on plasma fatty acid composition and metabolic syndrome in a population at high cardiovascular risk.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/fa993d5cc5604dc49ddae5bce554aa45
work_keys_str_mv AT jordimaynerisperxachs effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT aleixsalavila effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT maribelchisaguano effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT anaicastellote effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT ramonestruch effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT mariaisabelcovas effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT montserratfito effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT jordisalassalvado effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT miguelamartinezgonzalez effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT rosalamuelaraventos effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT emilioros effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT mcarmenlopezsabater effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
AT predimedstudyinvestigators effectsof1yearinterventionwithamediterraneandietonplasmafattyacidcompositionandmetabolicsyndromeinapopulationathighcardiovascularrisk
_version_ 1718421838786199552