Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA

Nop9 is a conserved small ribosomal subunit biogenesis factor. Here, Zhang et al. show that Nop9, in complex with RNA, adopts a C-shaped fold formed from 11 Pumillo repeats and propose that Nop9 inhibits premature cleavage of 20S pre-rRNA by inhibiting the Nob1 nuclease.

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Detalles Bibliográficos
Autores principales: Jun Zhang, Kathleen L. McCann, Chen Qiu, Lauren E. Gonzalez, Susan J. Baserga, Traci M. Tanaka Hall
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/faa28510bd764afbbb1cc91b25bbfcb8
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Descripción
Sumario:Nop9 is a conserved small ribosomal subunit biogenesis factor. Here, Zhang et al. show that Nop9, in complex with RNA, adopts a C-shaped fold formed from 11 Pumillo repeats and propose that Nop9 inhibits premature cleavage of 20S pre-rRNA by inhibiting the Nob1 nuclease.