Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide

Common Fragile Sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Here the authors use genome-wide and single cell techniques to assess how replication timing and transcriptional activity correlate with genome st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Olivier Brison, Sami El-Hilali, Dana Azar, Stéphane Koundrioukoff, Mélanie Schmidt, Viola Nähse, Yan Jaszczyszyn, Anne-Marie Lachages, Bernard Dutrillaux, Claude Thermes, Michelle Debatisse, Chun-Long Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/faa892657e9143c2a1486f882b9f0db1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:faa892657e9143c2a1486f882b9f0db1
record_format	dspace
spelling	oai:doaj.org-article:faa892657e9143c2a1486f882b9f0db12021-12-02T17:01:31ZTranscription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide10.1038/s41467-019-13674-52041-1723https://doaj.org/article/faa892657e9143c2a1486f882b9f0db12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13674-5https://doaj.org/toc/2041-1723Common Fragile Sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Here the authors use genome-wide and single cell techniques to assess how replication timing and transcriptional activity correlate with genome stability.Olivier BrisonSami El-HilaliDana AzarStéphane KoundrioukoffMélanie SchmidtViola NähseYan JaszczyszynAnne-Marie LachagesBernard DutrillauxClaude ThermesMichelle DebatisseChun-Long ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olivier Brison Sami El-Hilali Dana Azar Stéphane Koundrioukoff Mélanie Schmidt Viola Nähse Yan Jaszczyszyn Anne-Marie Lachages Bernard Dutrillaux Claude Thermes Michelle Debatisse Chun-Long Chen Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
description	Common Fragile Sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Here the authors use genome-wide and single cell techniques to assess how replication timing and transcriptional activity correlate with genome stability.
format	article
author	Olivier Brison Sami El-Hilali Dana Azar Stéphane Koundrioukoff Mélanie Schmidt Viola Nähse Yan Jaszczyszyn Anne-Marie Lachages Bernard Dutrillaux Claude Thermes Michelle Debatisse Chun-Long Chen
author_facet	Olivier Brison Sami El-Hilali Dana Azar Stéphane Koundrioukoff Mélanie Schmidt Viola Nähse Yan Jaszczyszyn Anne-Marie Lachages Bernard Dutrillaux Claude Thermes Michelle Debatisse Chun-Long Chen
author_sort	Olivier Brison
title	Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
title_short	Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
title_full	Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
title_fullStr	Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
title_full_unstemmed	Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
title_sort	transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/faa892657e9143c2a1486f882b9f0db1
work_keys_str_mv	AT olivierbrison transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT samielhilali transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT danaazar transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT stephanekoundrioukoff transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT melanieschmidt transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT violanahse transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT yanjaszczyszyn transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT annemarielachages transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT bernarddutrillaux transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT claudethermes transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT michelledebatisse transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide AT chunlongchen transcriptionmediatedorganizationofthereplicationinitiationprogramacrosslargegenessetscommonfragilesitesgenomewide
_version_	1718382125064912896

Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide

Ejemplares similares