Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregati...

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Autores principales: Yair Razvag, Yair Neve-Oz, Julia Sajman, Meital Reches, Eilon Sherman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/faa9064c87e14a9ba2dcce63fc9bc33e
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Sumario:T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregation model of TCR signalling.