Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregati...

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Autores principales:	Yair Razvag, Yair Neve-Oz, Julia Sajman, Meital Reches, Eilon Sherman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/faa9064c87e14a9ba2dcce63fc9bc33e
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spelling	oai:doaj.org-article:faa9064c87e14a9ba2dcce63fc9bc33e2021-12-02T17:33:17ZNanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation10.1038/s41467-018-03127-w2041-1723https://doaj.org/article/faa9064c87e14a9ba2dcce63fc9bc33e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03127-whttps://doaj.org/toc/2041-1723T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregation model of TCR signalling.Yair RazvagYair Neve-OzJulia SajmanMeital RechesEilon ShermanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yair Razvag Yair Neve-Oz Julia Sajman Meital Reches Eilon Sherman Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
description	T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregation model of TCR signalling.
format	article
author	Yair Razvag Yair Neve-Oz Julia Sajman Meital Reches Eilon Sherman
author_facet	Yair Razvag Yair Neve-Oz Julia Sajman Meital Reches Eilon Sherman
author_sort	Yair Razvag
title	Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
title_short	Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
title_full	Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
title_fullStr	Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
title_full_unstemmed	Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
title_sort	nanoscale kinetic segregation of tcr and cd45 in engaged microvilli facilitates early t cell activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/faa9064c87e14a9ba2dcce63fc9bc33e
work_keys_str_mv	AT yairrazvag nanoscalekineticsegregationoftcrandcd45inengagedmicrovillifacilitatesearlytcellactivation AT yairneveoz nanoscalekineticsegregationoftcrandcd45inengagedmicrovillifacilitatesearlytcellactivation AT juliasajman nanoscalekineticsegregationoftcrandcd45inengagedmicrovillifacilitatesearlytcellactivation AT meitalreches nanoscalekineticsegregationoftcrandcd45inengagedmicrovillifacilitatesearlytcellactivation AT eilonsherman nanoscalekineticsegregationoftcrandcd45inengagedmicrovillifacilitatesearlytcellactivation
_version_	1718380037954076672

Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

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