Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit

The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C activity towards its centrosomal substrate Aurora A.

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Autores principales:	Francesco Meghini, Torcato Martins, Xavier Tait, Kazuyuki Fujimitsu, Hiroyuki Yamano, David M. Glover, Yuu Kimata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/faaaa862e214408085422a57ff18cb1a
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spelling	oai:doaj.org-article:faaaa862e214408085422a57ff18cb1a2021-12-02T15:34:57ZTargeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit10.1038/ncomms126072041-1723https://doaj.org/article/faaaa862e214408085422a57ff18cb1a2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12607https://doaj.org/toc/2041-1723The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C activity towards its centrosomal substrate Aurora A.Francesco MeghiniTorcato MartinsXavier TaitKazuyuki FujimitsuHiroyuki YamanoDavid M. GloverYuu KimataNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesco Meghini Torcato Martins Xavier Tait Kazuyuki Fujimitsu Hiroyuki Yamano David M. Glover Yuu Kimata Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
description	The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C activity towards its centrosomal substrate Aurora A.
format	article
author	Francesco Meghini Torcato Martins Xavier Tait Kazuyuki Fujimitsu Hiroyuki Yamano David M. Glover Yuu Kimata
author_facet	Francesco Meghini Torcato Martins Xavier Tait Kazuyuki Fujimitsu Hiroyuki Yamano David M. Glover Yuu Kimata
author_sort	Francesco Meghini
title	Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
title_short	Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
title_full	Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
title_fullStr	Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
title_full_unstemmed	Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
title_sort	targeting of fzr/cdh1 for timely activation of the apc/c at the centrosome during mitotic exit
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/faaaa862e214408085422a57ff18cb1a
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Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit

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