Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit

Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit

The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C activity towards its centrosomal substrate Aurora A.

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Autores principales: Francesco Meghini, Torcato Martins, Xavier Tait, Kazuyuki Fujimitsu, Hiroyuki Yamano, David M. Glover, Yuu Kimata
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/faaaa862e214408085422a57ff18cb1a
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