Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

A key challenge is to find/re-purpose approved drugs that could be used in humans to induce autophagy-associated clearance of neurodegenerative proteins. Here, authors demonstrate that felodipine, an anti-hypertensive drug, can induce autophagy and clear a variety of aggregated neurodegenerative dis...

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Autores principales:	Farah H. Siddiqi, Fiona M. Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D. Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo J. R. Fernandes, Andrew Bassett, Eric Karran, Bruce L. Miller, Angeleen Fleming, David C. Rubinsztein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/faadda18e0ed4177b4aba46493d7b981
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spelling	oai:doaj.org-article:faadda18e0ed4177b4aba46493d7b9812021-12-02T15:36:06ZFelodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing10.1038/s41467-019-09494-22041-1723https://doaj.org/article/faadda18e0ed4177b4aba46493d7b9812019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09494-2https://doaj.org/toc/2041-1723A key challenge is to find/re-purpose approved drugs that could be used in humans to induce autophagy-associated clearance of neurodegenerative proteins. Here, authors demonstrate that felodipine, an anti-hypertensive drug, can induce autophagy and clear a variety of aggregated neurodegenerative disease-associated proteins in mouse brains at plasma concentrations similar to those that would be seen in humans taking the drug.Farah H. SiddiqiFiona M. MenziesAna LopezEleanna StamatakouCansu KarabiyikRodrigo UreshinoThomas RickettsMaria Jimenez-SanchezMiguel Angel EstebanLiangxue LaiMicky D. TortorellaZhiwei LuoHao LiuEmmanouil MetzakopianHugo J. R. FernandesAndrew BassettEric KarranBruce L. MillerAngeleen FlemingDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Farah H. Siddiqi Fiona M. Menzies Ana Lopez Eleanna Stamatakou Cansu Karabiyik Rodrigo Ureshino Thomas Ricketts Maria Jimenez-Sanchez Miguel Angel Esteban Liangxue Lai Micky D. Tortorella Zhiwei Luo Hao Liu Emmanouil Metzakopian Hugo J. R. Fernandes Andrew Bassett Eric Karran Bruce L. Miller Angeleen Fleming David C. Rubinsztein Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
description	A key challenge is to find/re-purpose approved drugs that could be used in humans to induce autophagy-associated clearance of neurodegenerative proteins. Here, authors demonstrate that felodipine, an anti-hypertensive drug, can induce autophagy and clear a variety of aggregated neurodegenerative disease-associated proteins in mouse brains at plasma concentrations similar to those that would be seen in humans taking the drug.
format	article
author	Farah H. Siddiqi Fiona M. Menzies Ana Lopez Eleanna Stamatakou Cansu Karabiyik Rodrigo Ureshino Thomas Ricketts Maria Jimenez-Sanchez Miguel Angel Esteban Liangxue Lai Micky D. Tortorella Zhiwei Luo Hao Liu Emmanouil Metzakopian Hugo J. R. Fernandes Andrew Bassett Eric Karran Bruce L. Miller Angeleen Fleming David C. Rubinsztein
author_facet	Farah H. Siddiqi Fiona M. Menzies Ana Lopez Eleanna Stamatakou Cansu Karabiyik Rodrigo Ureshino Thomas Ricketts Maria Jimenez-Sanchez Miguel Angel Esteban Liangxue Lai Micky D. Tortorella Zhiwei Luo Hao Liu Emmanouil Metzakopian Hugo J. R. Fernandes Andrew Bassett Eric Karran Bruce L. Miller Angeleen Fleming David C. Rubinsztein
author_sort	Farah H. Siddiqi
title	Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
title_short	Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
title_full	Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
title_fullStr	Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
title_full_unstemmed	Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
title_sort	felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/faadda18e0ed4177b4aba46493d7b981
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Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

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