Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases

Reorganisation of the extracellular matrix (ECM) controls processes involving epithelial-mesenchymal transition (EMT). Here, the authors show that EMT occurring in epithelial cells on a fabricated nano-engineered cell adhesion surface is triggered by mechanical cues from the ECM.

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Autores principales:	JinSeok Park, Deok-Ho Kim, Sagar R. Shah, Hong-Nam Kim, Kshitiz, Peter Kim, Alfredo Quiñones-Hinojosa, Andre Levchenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fab1f839a32141ee848340f076fa446a
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spelling	oai:doaj.org-article:fab1f839a32141ee848340f076fa446a2021-12-02T17:01:47ZSwitch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases10.1038/s41467-019-10729-52041-1723https://doaj.org/article/fab1f839a32141ee848340f076fa446a2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10729-5https://doaj.org/toc/2041-1723Reorganisation of the extracellular matrix (ECM) controls processes involving epithelial-mesenchymal transition (EMT). Here, the authors show that EMT occurring in epithelial cells on a fabricated nano-engineered cell adhesion surface is triggered by mechanical cues from the ECM.JinSeok ParkDeok-Ho KimSagar R. ShahHong-Nam KimKshitizPeter KimAlfredo Quiñones-HinojosaAndre LevchenkoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q JinSeok Park Deok-Ho Kim Sagar R. Shah Hong-Nam Kim Kshitiz Peter Kim Alfredo Quiñones-Hinojosa Andre Levchenko Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
description	Reorganisation of the extracellular matrix (ECM) controls processes involving epithelial-mesenchymal transition (EMT). Here, the authors show that EMT occurring in epithelial cells on a fabricated nano-engineered cell adhesion surface is triggered by mechanical cues from the ECM.
format	article
author	JinSeok Park Deok-Ho Kim Sagar R. Shah Hong-Nam Kim Kshitiz Peter Kim Alfredo Quiñones-Hinojosa Andre Levchenko
author_facet	JinSeok Park Deok-Ho Kim Sagar R. Shah Hong-Nam Kim Kshitiz Peter Kim Alfredo Quiñones-Hinojosa Andre Levchenko
author_sort	JinSeok Park
title	Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
title_short	Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
title_full	Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
title_fullStr	Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
title_full_unstemmed	Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
title_sort	switch-like enhancement of epithelial-mesenchymal transition by yap through feedback regulation of wt1 and rho-family gtpases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fab1f839a32141ee848340f076fa446a
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Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases

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