Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

Ribbon synapses in our sensory nervous system are central to hearing and sight, yet little is known about how these synapses are assembled and maintained during development. In this study, authors use live imaging techniques to monitor ribbon appearance, loss and maintenance in a retinal circuit dur...

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Autores principales:	Haruhisa Okawa, Wan-Qing Yu, Ulf Matti, Karin Schwarz, Benjamin Odermatt, Haining Zhong, Yoshihiko Tsukamoto, Leon Lagnado, Fred Rieke, Frank Schmitz, Rachel O. L. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fab6c0f6151e4201945361b7613c377a
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spelling	oai:doaj.org-article:fab6c0f6151e4201945361b7613c377a2021-12-02T14:40:01ZDynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system10.1038/s41467-019-10123-12041-1723https://doaj.org/article/fab6c0f6151e4201945361b7613c377a2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10123-1https://doaj.org/toc/2041-1723Ribbon synapses in our sensory nervous system are central to hearing and sight, yet little is known about how these synapses are assembled and maintained during development. In this study, authors use live imaging techniques to monitor ribbon appearance, loss and maintenance in a retinal circuit during development to show that nascent synapses comprising of both ribbons and PSD95 are more stable over time compared to contacts without ribbons.Haruhisa OkawaWan-Qing YuUlf MattiKarin SchwarzBenjamin OdermattHaining ZhongYoshihiko TsukamotoLeon LagnadoFred RiekeFrank SchmitzRachel O. L. WongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haruhisa Okawa Wan-Qing Yu Ulf Matti Karin Schwarz Benjamin Odermatt Haining Zhong Yoshihiko Tsukamoto Leon Lagnado Fred Rieke Frank Schmitz Rachel O. L. Wong Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system
description	Ribbon synapses in our sensory nervous system are central to hearing and sight, yet little is known about how these synapses are assembled and maintained during development. In this study, authors use live imaging techniques to monitor ribbon appearance, loss and maintenance in a retinal circuit during development to show that nascent synapses comprising of both ribbons and PSD95 are more stable over time compared to contacts without ribbons.
format	article
author	Haruhisa Okawa Wan-Qing Yu Ulf Matti Karin Schwarz Benjamin Odermatt Haining Zhong Yoshihiko Tsukamoto Leon Lagnado Fred Rieke Frank Schmitz Rachel O. L. Wong
author_facet	Haruhisa Okawa Wan-Qing Yu Ulf Matti Karin Schwarz Benjamin Odermatt Haining Zhong Yoshihiko Tsukamoto Leon Lagnado Fred Rieke Frank Schmitz Rachel O. L. Wong
author_sort	Haruhisa Okawa
title	Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system
title_short	Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system
title_full	Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system
title_fullStr	Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system
title_full_unstemmed	Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system
title_sort	dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fab6c0f6151e4201945361b7613c377a
work_keys_str_mv	AT haruhisaokawa dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT wanqingyu dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT ulfmatti dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT karinschwarz dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT benjaminodermatt dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT hainingzhong dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT yoshihikotsukamoto dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT leonlagnado dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT fredrieke dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT frankschmitz dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem AT rachelolwong dynamicassemblyofribbonsynapsesandcircuitmaintenanceinavertebratesensorysystem
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Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system

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