Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder

Abstract Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve...

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Autores principales:	Eun Jin Yoon, Jung-Seok Choi, Heejung Kim, Bo Kyung Sohn, Hee Yeon Jung, Jun-Young Lee, Dai-Jin Kim, Sun-Won Park, Yu Kyeong Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fabe10740add4b8b9c576cac3491ea83
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spelling	oai:doaj.org-article:fabe10740add4b8b9c576cac3491ea832021-12-02T16:05:59ZAltered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder10.1038/s41598-017-06057-72045-2322https://doaj.org/article/fabe10740add4b8b9c576cac3491ea832017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06057-7https://doaj.org/toc/2045-2322Abstract Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve a clear understanding of the neurobiological features of IGD, we aimed to identify morphological and functional changes in IGD and compare them with those in AUD. Individuals with IGD showed larger volume in the hippocampus/amygdala and precuneus than healthy controls (HCs). The volume in the hippocampus positively correlated with the symptom severity of IGD. Moreover, functional connectivity analysis with the hippocampus/amygdala cluster revealed that the left ventromedial prefrontal cortex showed stronger functional connectivity in individuals with IGD compared to those with AUD. In contrast, individuals with AUD exhibited the smaller cerebellar volume and thinner medial frontal cortex than HCs. The volume in the cerebellum correlated with impaired working memory function as well as duration of illness in AUD group. Findings suggested that altered volume and functional connectivity in the hippocampus/amygdala in IGD might be associated with abnormally enhanced memory process of gaming-related cues, while abnormal cortical changes and cognitive impairments in AUD might be associated with neurotoxic effects of alcohol.Eun Jin YoonJung-Seok ChoiHeejung KimBo Kyung SohnHee Yeon JungJun-Young LeeDai-Jin KimSun-Won ParkYu Kyeong KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eun Jin Yoon Jung-Seok Choi Heejung Kim Bo Kyung Sohn Hee Yeon Jung Jun-Young Lee Dai-Jin Kim Sun-Won Park Yu Kyeong Kim Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder
description	Abstract Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve a clear understanding of the neurobiological features of IGD, we aimed to identify morphological and functional changes in IGD and compare them with those in AUD. Individuals with IGD showed larger volume in the hippocampus/amygdala and precuneus than healthy controls (HCs). The volume in the hippocampus positively correlated with the symptom severity of IGD. Moreover, functional connectivity analysis with the hippocampus/amygdala cluster revealed that the left ventromedial prefrontal cortex showed stronger functional connectivity in individuals with IGD compared to those with AUD. In contrast, individuals with AUD exhibited the smaller cerebellar volume and thinner medial frontal cortex than HCs. The volume in the cerebellum correlated with impaired working memory function as well as duration of illness in AUD group. Findings suggested that altered volume and functional connectivity in the hippocampus/amygdala in IGD might be associated with abnormally enhanced memory process of gaming-related cues, while abnormal cortical changes and cognitive impairments in AUD might be associated with neurotoxic effects of alcohol.
format	article
author	Eun Jin Yoon Jung-Seok Choi Heejung Kim Bo Kyung Sohn Hee Yeon Jung Jun-Young Lee Dai-Jin Kim Sun-Won Park Yu Kyeong Kim
author_facet	Eun Jin Yoon Jung-Seok Choi Heejung Kim Bo Kyung Sohn Hee Yeon Jung Jun-Young Lee Dai-Jin Kim Sun-Won Park Yu Kyeong Kim
author_sort	Eun Jin Yoon
title	Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder
title_short	Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder
title_full	Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder
title_fullStr	Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder
title_full_unstemmed	Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder
title_sort	altered hippocampal volume and functional connectivity in males with internet gaming disorder comparing to those with alcohol use disorder
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fabe10740add4b8b9c576cac3491ea83
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Altered hippocampal volume and functional connectivity in males with Internet gaming disorder comparing to those with alcohol use disorder

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