Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography

Objectives: To investigate microstructural alterations of explanted long-term central venous catheters of totally implantable venous access devices, using micro-computed tomography. Methods: A total of 16 catheters (9 made of silicone and 7 made of polyurethane), all non-fractured, have been analyze...

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Autores principales:	Daniele Panetta, Lara Tollapi, Adriana Paolicchi, Elisa Marri, Giacomo Aringhieri, Davide Caramella
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fac428804c9645fc8d47b9a885eac2c9
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spelling	oai:doaj.org-article:fac428804c9645fc8d47b9a885eac2c92021-12-03T23:33:43ZComparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography2050-312110.1177/20503121211059949https://doaj.org/article/fac428804c9645fc8d47b9a885eac2c92021-11-01T00:00:00Zhttps://doi.org/10.1177/20503121211059949https://doaj.org/toc/2050-3121Objectives: To investigate microstructural alterations of explanted long-term central venous catheters of totally implantable venous access devices, using micro-computed tomography. Methods: A total of 16 catheters (9 made of silicone and 7 made of polyurethane), all non-fractured, have been analyzed in this study. Eight catheters were implanted for an average duration of 994 days (min–max: 98–2731 days), while the remaining eight catheters (four for each material, forming the SIref and PUref control groups) were analyzed before implant and used as a reference. X-ray micro-computed tomography was used to reconstruct the three-dimensional geometry of selected segments of each catheter (ca. 10 cm per sample). Results: Morphometric analysis of the catheters revealed increases wall thickness and section area in the polyurethane group as compared with the reference central venous catheters of the same materials (wall thickness: 403 ± 12 μm in the polyurethane (PU) group vs 382 ± 4 μm in PUref, p = 0.014; wall cross-section area: 2.04 ± 0.09 mm 2 in PU vs 1.91 ± 0.03 mm 2 in PUref, p = 0.04), whereas implanted silicone catheters showed a larger luminal cross section as compared with their controls (lumen cross-section area = 0.851 ± 0.020 mm 2 in silicone (SI) group vs 0.811 ± 0.007 mm 2 in SIref, p = 0.007). All analyzed samples in this study presented some type of alteration in the catheter walls, namely, hyperdense spots (below 0.1 mm size), air gaps/bubbles and displacements of inner and outer axes causing heterogeneous wall thickness. The incidence of air gaps showed no difference with respect to both material type and duration of implant, whereas the SI group revealed more hyperdense spots as compared to all other groups. Conclusion: Morphological change and local structural alteration can occur in both silicone and polyurethane catheters. This evidence suggests the need for further studies connecting those morphological changes with modification of mechanical robustness, which ultimately can play a role for patient safety.Daniele PanettaLara TollapiAdriana PaolicchiElisa MarriGiacomo AringhieriDavide CaramellaSAGE PublishingarticleMedicine (General)R5-920ENSAGE Open Medicine, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Daniele Panetta Lara Tollapi Adriana Paolicchi Elisa Marri Giacomo Aringhieri Davide Caramella Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography
description	Objectives: To investigate microstructural alterations of explanted long-term central venous catheters of totally implantable venous access devices, using micro-computed tomography. Methods: A total of 16 catheters (9 made of silicone and 7 made of polyurethane), all non-fractured, have been analyzed in this study. Eight catheters were implanted for an average duration of 994 days (min–max: 98–2731 days), while the remaining eight catheters (four for each material, forming the SIref and PUref control groups) were analyzed before implant and used as a reference. X-ray micro-computed tomography was used to reconstruct the three-dimensional geometry of selected segments of each catheter (ca. 10 cm per sample). Results: Morphometric analysis of the catheters revealed increases wall thickness and section area in the polyurethane group as compared with the reference central venous catheters of the same materials (wall thickness: 403 ± 12 μm in the polyurethane (PU) group vs 382 ± 4 μm in PUref, p = 0.014; wall cross-section area: 2.04 ± 0.09 mm 2 in PU vs 1.91 ± 0.03 mm 2 in PUref, p = 0.04), whereas implanted silicone catheters showed a larger luminal cross section as compared with their controls (lumen cross-section area = 0.851 ± 0.020 mm 2 in silicone (SI) group vs 0.811 ± 0.007 mm 2 in SIref, p = 0.007). All analyzed samples in this study presented some type of alteration in the catheter walls, namely, hyperdense spots (below 0.1 mm size), air gaps/bubbles and displacements of inner and outer axes causing heterogeneous wall thickness. The incidence of air gaps showed no difference with respect to both material type and duration of implant, whereas the SI group revealed more hyperdense spots as compared to all other groups. Conclusion: Morphological change and local structural alteration can occur in both silicone and polyurethane catheters. This evidence suggests the need for further studies connecting those morphological changes with modification of mechanical robustness, which ultimately can play a role for patient safety.
format	article
author	Daniele Panetta Lara Tollapi Adriana Paolicchi Elisa Marri Giacomo Aringhieri Davide Caramella
author_facet	Daniele Panetta Lara Tollapi Adriana Paolicchi Elisa Marri Giacomo Aringhieri Davide Caramella
author_sort	Daniele Panetta
title	Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography
title_short	Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography
title_full	Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography
title_fullStr	Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography
title_full_unstemmed	Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography
title_sort	comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/fac428804c9645fc8d47b9a885eac2c9
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Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography

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