Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?

Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial integrity by targeting specific mitochondrial quality control pathways in neurodegenerative diseases, such as Parkinson’s disease, Huntington’s disease, and Alzheimer’s disease. In addition to ATP synthesis, mi...

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Autores principales:	Di Hu, Zunren Liu, Xin Qi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neurodegenerative diseases mitochondrial quality control mitochondrial proteostasis mitochondrial dynamics mitophagy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/fac850afd7a946c58e8be85f037920d0
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spelling	oai:doaj.org-article:fac850afd7a946c58e8be85f037920d02021-11-12T06:59:06ZMitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?1662-453X10.3389/fnins.2021.746873https://doaj.org/article/fac850afd7a946c58e8be85f037920d02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.746873/fullhttps://doaj.org/toc/1662-453XMany lines of evidence have indicated the therapeutic potential of rescuing mitochondrial integrity by targeting specific mitochondrial quality control pathways in neurodegenerative diseases, such as Parkinson’s disease, Huntington’s disease, and Alzheimer’s disease. In addition to ATP synthesis, mitochondria are critical regulators of ROS production, lipid metabolism, calcium buffering, and cell death. The mitochondrial unfolded protein response, mitochondrial dynamics, and mitophagy are the three main quality control mechanisms responsible for maintaining mitochondrial proteostasis and bioenergetics. The proper functioning of these complex processes is necessary to surveil and restore mitochondrial homeostasis and the healthy pool of mitochondria in cells. Mitochondrial dysfunction occurs early and causally in disease pathogenesis. A significant accumulation of mitochondrial damage resulting from compromised quality control pathways leads to the development of neuropathology. Moreover, genetic or pharmaceutical manipulation targeting the mitochondrial quality control mechanisms can sufficiently rescue mitochondrial integrity and ameliorate disease progression. Thus, therapies that can improve mitochondrial quality control have great promise for the treatment of neurodegenerative diseases. In this review, we summarize recent progress in the field that underscores the essential role of impaired mitochondrial quality control pathways in the pathogenesis of neurodegenerative diseases. We also discuss the translational approaches targeting mitochondrial function, with a focus on the restoration of mitochondrial integrity, including mitochondrial dynamics, mitophagy, and mitochondrial proteostasis.Di HuZunren LiuXin QiXin QiFrontiers Media S.A.articleneurodegenerative diseasesmitochondrial quality controlmitochondrial proteostasismitochondrial dynamicsmitophagyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurodegenerative diseases mitochondrial quality control mitochondrial proteostasis mitochondrial dynamics mitophagy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	neurodegenerative diseases mitochondrial quality control mitochondrial proteostasis mitochondrial dynamics mitophagy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Di Hu Zunren Liu Xin Qi Xin Qi Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?
description	Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial integrity by targeting specific mitochondrial quality control pathways in neurodegenerative diseases, such as Parkinson’s disease, Huntington’s disease, and Alzheimer’s disease. In addition to ATP synthesis, mitochondria are critical regulators of ROS production, lipid metabolism, calcium buffering, and cell death. The mitochondrial unfolded protein response, mitochondrial dynamics, and mitophagy are the three main quality control mechanisms responsible for maintaining mitochondrial proteostasis and bioenergetics. The proper functioning of these complex processes is necessary to surveil and restore mitochondrial homeostasis and the healthy pool of mitochondria in cells. Mitochondrial dysfunction occurs early and causally in disease pathogenesis. A significant accumulation of mitochondrial damage resulting from compromised quality control pathways leads to the development of neuropathology. Moreover, genetic or pharmaceutical manipulation targeting the mitochondrial quality control mechanisms can sufficiently rescue mitochondrial integrity and ameliorate disease progression. Thus, therapies that can improve mitochondrial quality control have great promise for the treatment of neurodegenerative diseases. In this review, we summarize recent progress in the field that underscores the essential role of impaired mitochondrial quality control pathways in the pathogenesis of neurodegenerative diseases. We also discuss the translational approaches targeting mitochondrial function, with a focus on the restoration of mitochondrial integrity, including mitochondrial dynamics, mitophagy, and mitochondrial proteostasis.
format	article
author	Di Hu Zunren Liu Xin Qi Xin Qi
author_facet	Di Hu Zunren Liu Xin Qi Xin Qi
author_sort	Di Hu
title	Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?
title_short	Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?
title_full	Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?
title_fullStr	Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?
title_full_unstemmed	Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?
title_sort	mitochondrial quality control strategies: potential therapeutic targets for neurodegenerative diseases?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fac850afd7a946c58e8be85f037920d0
work_keys_str_mv	AT dihu mitochondrialqualitycontrolstrategiespotentialtherapeutictargetsforneurodegenerativediseases AT zunrenliu mitochondrialqualitycontrolstrategiespotentialtherapeutictargetsforneurodegenerativediseases AT xinqi mitochondrialqualitycontrolstrategiespotentialtherapeutictargetsforneurodegenerativediseases AT xinqi mitochondrialqualitycontrolstrategiespotentialtherapeutictargetsforneurodegenerativediseases
_version_	1718431146387177472

Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?

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