Effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.

<h4>Background</h4>Although bridge to lung transplantation (BTT) with extracorporeal membrane oxygenation (ECMO) is increasingly performed, the impact of BTT and its duration on post-transplant outcomes are unclear.<h4>Methods</h4>We retrospectively reviewed medical records o...

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Autores principales:	Dong Kyu Oh, Sang-Bum Hong, Tae Sun Shim, Dong Kwan Kim, Sehoon Choi, Geun Dong Lee, Won Kim, Seung-Il Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/faca5b380fc64782a006550830d3373b
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spelling	oai:doaj.org-article:faca5b380fc64782a006550830d3373b2021-12-02T20:09:49ZEffects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.1932-620310.1371/journal.pone.0253520https://doaj.org/article/faca5b380fc64782a006550830d3373b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253520https://doaj.org/toc/1932-6203<h4>Background</h4>Although bridge to lung transplantation (BTT) with extracorporeal membrane oxygenation (ECMO) is increasingly performed, the impact of BTT and its duration on post-transplant outcomes are unclear.<h4>Methods</h4>We retrospectively reviewed medical records of adult patients who underwent lung or heart-lung transplantation in our institution between January 2008 and December 2018. Data were compared in patients who did (n = 41; BTT) and did not (n = 36; non-BTT) require pre-transplant ECMO support. Data were also compared in patients who underwent short-term (<14 days; n = 21; ST-BTT) and long-term (≥14 days; n = 20; LT-BTT) BTTs.<h4>Results</h4>Among 77 patients included, 51 (66.2%) were male and median age was 53 years. The median bridging time in the BTT group was 13 days (interquartile range [IQR], 7-19 days). Although simplified acute physiologic score II was significantly higher in the BTT group (median, 35; IQR, 31-49 in BTT group vs. median, 12; IQR, 7-19 in non-BTT group; p<0.001), 1-year (73.2% vs. 80.6%; p = 0.361) and 5-year (61.5% vs. 61.5%; p = 0.765) post-transplant survival rates were comparable in both groups. Comparison of ST- and LT-BTT subgroups showed that 1-year (90.5% vs. 55.0%; p = 0.009) and 5-year (73.0% vs. 48.1%; p = 0.030) post-transplant survival rates were significantly higher in ST-BTT group. In age and sex adjusted model, the LT-BTT was an independent risk factor for 1-year post-transplant mortality (hazard ratio, 3.019; 95% confidence interval, 1.119-8.146; p = 0.029), whereas the ST-BTT was not.<h4>Conclusions</h4>Despite the severe illness, the BTT group showed favorable post-transplantation outcomes, particularly those bridged for less than 14 days.Dong Kyu OhSang-Bum HongTae Sun ShimDong Kwan KimSehoon ChoiGeun Dong LeeWon KimSeung-Il ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253520 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Kyu Oh Sang-Bum Hong Tae Sun Shim Dong Kwan Kim Sehoon Choi Geun Dong Lee Won Kim Seung-Il Park Effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.
description	<h4>Background</h4>Although bridge to lung transplantation (BTT) with extracorporeal membrane oxygenation (ECMO) is increasingly performed, the impact of BTT and its duration on post-transplant outcomes are unclear.<h4>Methods</h4>We retrospectively reviewed medical records of adult patients who underwent lung or heart-lung transplantation in our institution between January 2008 and December 2018. Data were compared in patients who did (n = 41; BTT) and did not (n = 36; non-BTT) require pre-transplant ECMO support. Data were also compared in patients who underwent short-term (<14 days; n = 21; ST-BTT) and long-term (≥14 days; n = 20; LT-BTT) BTTs.<h4>Results</h4>Among 77 patients included, 51 (66.2%) were male and median age was 53 years. The median bridging time in the BTT group was 13 days (interquartile range [IQR], 7-19 days). Although simplified acute physiologic score II was significantly higher in the BTT group (median, 35; IQR, 31-49 in BTT group vs. median, 12; IQR, 7-19 in non-BTT group; p<0.001), 1-year (73.2% vs. 80.6%; p = 0.361) and 5-year (61.5% vs. 61.5%; p = 0.765) post-transplant survival rates were comparable in both groups. Comparison of ST- and LT-BTT subgroups showed that 1-year (90.5% vs. 55.0%; p = 0.009) and 5-year (73.0% vs. 48.1%; p = 0.030) post-transplant survival rates were significantly higher in ST-BTT group. In age and sex adjusted model, the LT-BTT was an independent risk factor for 1-year post-transplant mortality (hazard ratio, 3.019; 95% confidence interval, 1.119-8.146; p = 0.029), whereas the ST-BTT was not.<h4>Conclusions</h4>Despite the severe illness, the BTT group showed favorable post-transplantation outcomes, particularly those bridged for less than 14 days.
format	article
author	Dong Kyu Oh Sang-Bum Hong Tae Sun Shim Dong Kwan Kim Sehoon Choi Geun Dong Lee Won Kim Seung-Il Park
author_facet	Dong Kyu Oh Sang-Bum Hong Tae Sun Shim Dong Kwan Kim Sehoon Choi Geun Dong Lee Won Kim Seung-Il Park
author_sort	Dong Kyu Oh
title	Effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.
title_short	Effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.
title_full	Effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.
title_fullStr	Effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.
title_full_unstemmed	Effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.
title_sort	effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/faca5b380fc64782a006550830d3373b
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Effects of the duration of bridge to lung transplantation with extracorporeal membrane oxygenation.

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