Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

Abstract Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition...

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Autores principales:	Muralidhar MN, Prasad SMVK, Kiran Kumar Battula, Giridharan NV, Rajender Rao Kalashikam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/facebc07e19a453c87d182ddca7bb4da
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spelling	oai:doaj.org-article:facebc07e19a453c87d182ddca7bb4da2021-12-02T16:07:56ZDifferential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity10.1038/s41598-017-09149-62045-2322https://doaj.org/article/facebc07e19a453c87d182ddca7bb4da2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09149-6https://doaj.org/toc/2045-2322Abstract Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition in the etiology of obesity has not been clearly delineated. The present study addresses this problem by selecting three rat strains (WNIN, F-344, SD) with different genetic backgrounds and exposing them to high calorie diets. Rat strains were fed HF, HS, and HFS diets and assessed for physical, metabolic, biochemical, inflammatory responses, and mRNA expression. Under these conditions: significant increase in body weight, visceral adiposity, oxidative stress and systemic pro-inflammatory status; the hallmarks of central obesity were noticed only in WNIN. Further, they developed altered glucose and lipid homeostasis by exhibiting insulin resistance, impaired glucose tolerance, dyslipidemia and fatty liver condition. The present study demonstrates that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment. It thus underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.Muralidhar MNPrasad SMVKKiran Kumar BattulaGiridharan NVRajender Rao KalashikamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muralidhar MN Prasad SMVK Kiran Kumar Battula Giridharan NV Rajender Rao Kalashikam Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
description	Abstract Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition in the etiology of obesity has not been clearly delineated. The present study addresses this problem by selecting three rat strains (WNIN, F-344, SD) with different genetic backgrounds and exposing them to high calorie diets. Rat strains were fed HF, HS, and HFS diets and assessed for physical, metabolic, biochemical, inflammatory responses, and mRNA expression. Under these conditions: significant increase in body weight, visceral adiposity, oxidative stress and systemic pro-inflammatory status; the hallmarks of central obesity were noticed only in WNIN. Further, they developed altered glucose and lipid homeostasis by exhibiting insulin resistance, impaired glucose tolerance, dyslipidemia and fatty liver condition. The present study demonstrates that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment. It thus underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.
format	article
author	Muralidhar MN Prasad SMVK Kiran Kumar Battula Giridharan NV Rajender Rao Kalashikam
author_facet	Muralidhar MN Prasad SMVK Kiran Kumar Battula Giridharan NV Rajender Rao Kalashikam
author_sort	Muralidhar MN
title	Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_short	Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_full	Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_fullStr	Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_full_unstemmed	Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
title_sort	differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/facebc07e19a453c87d182ddca7bb4da
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Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

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