Proliferation PET/CT Imaging of Salivary Gland Tumor

Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphi...

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Autor principal:	Ryogo Minamimoto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	4DST PET/CT cell proliferation imaging FDG PET/CT salivary gland tumor pleomorphic adenoma Warthin’s tumor Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fad3d8eca6e346fe9975a3a895069a53
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spelling	oai:doaj.org-article:fad3d8eca6e346fe9975a3a895069a532021-11-25T17:21:18ZProliferation PET/CT Imaging of Salivary Gland Tumor10.3390/diagnostics111120652075-4418https://doaj.org/article/fad3d8eca6e346fe9975a3a895069a532021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2065https://doaj.org/toc/2075-4418Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Here, we discuss 4′-[methyl-11C]-thiothymidine (4DST) PET, which provides cell proliferation imaging capable of demonstrating intense uptake in parotid carcinoma and Warthin’s tumor, but no uptake in parotid pleomorphic adenoma. This is the first report of the potential of proliferation PET/ computed tomography (CT) imaging for characterizing salivary gland tumors based on the molecular pathogenesis of the tumor.Ryogo MinamimotoMDPI AGarticle4DST PET/CTcell proliferation imagingFDG PET/CTsalivary gland tumorpleomorphic adenomaWarthin’s tumorMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2065, p 2065 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	4DST PET/CT cell proliferation imaging FDG PET/CT salivary gland tumor pleomorphic adenoma Warthin’s tumor Medicine (General) R5-920
spellingShingle	4DST PET/CT cell proliferation imaging FDG PET/CT salivary gland tumor pleomorphic adenoma Warthin’s tumor Medicine (General) R5-920 Ryogo Minamimoto Proliferation PET/CT Imaging of Salivary Gland Tumor
description	Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Here, we discuss 4′-[methyl-11C]-thiothymidine (4DST) PET, which provides cell proliferation imaging capable of demonstrating intense uptake in parotid carcinoma and Warthin’s tumor, but no uptake in parotid pleomorphic adenoma. This is the first report of the potential of proliferation PET/ computed tomography (CT) imaging for characterizing salivary gland tumors based on the molecular pathogenesis of the tumor.
format	article
author	Ryogo Minamimoto
author_facet	Ryogo Minamimoto
author_sort	Ryogo Minamimoto
title	Proliferation PET/CT Imaging of Salivary Gland Tumor
title_short	Proliferation PET/CT Imaging of Salivary Gland Tumor
title_full	Proliferation PET/CT Imaging of Salivary Gland Tumor
title_fullStr	Proliferation PET/CT Imaging of Salivary Gland Tumor
title_full_unstemmed	Proliferation PET/CT Imaging of Salivary Gland Tumor
title_sort	proliferation pet/ct imaging of salivary gland tumor
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fad3d8eca6e346fe9975a3a895069a53
work_keys_str_mv	AT ryogominamimoto proliferationpetctimagingofsalivaryglandtumor
_version_	1718412507322777600

Proliferation PET/CT Imaging of Salivary Gland Tumor

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