Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

The immunological synapse allows antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells, which ultimately shape the immune response. The relative effect of stimulatory and inhibitory signals is influenced by the activation state of the APC, which is determ...

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Bibliographic Details
Main Authors: Michael C Kiritsy, Katelyn McCann, Daniel Mott, Steven M Holland, Samuel M Behar, Christopher M Sassetti, Andrew J Olive
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
IFN gamma
APC function
complex I
PD-L1 regulation
mitochondrial respiration
immunometabolism
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/fad7299fdf484cf5967a11a43468f79a
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https://doaj.org/article/fad7299fdf484cf5967a11a43468f79a

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