Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice

Abstract Modern life involves chronic circadian disruption through artificial light and these disruptions are associated with numerous mental and physical health maladies. Because the developing nervous system is particularly vulnerable to perturbation, we hypothesized that early-life circadian disr...

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Autores principales:	Benjamin L. Smarr, Azure D. Grant, Luz Perez, Irving Zucker, Lance J. Kriegsfeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fadafcf1d26349c2a74f8059231cf359
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spelling	oai:doaj.org-article:fadafcf1d26349c2a74f8059231cf3592021-12-02T11:40:53ZMaternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice10.1038/s41598-017-03406-42045-2322https://doaj.org/article/fadafcf1d26349c2a74f8059231cf3592017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03406-4https://doaj.org/toc/2045-2322Abstract Modern life involves chronic circadian disruption through artificial light and these disruptions are associated with numerous mental and physical health maladies. Because the developing nervous system is particularly vulnerable to perturbation, we hypothesized that early-life circadian disruption would negatively impact offspring development and adult function. Pregnant mice were subjected to chronic circadian disruption from the time of uterine implantation through weaning. To dissociate in utero from postnatal effects, a subset of litters was cross-fostered at birth from disrupted dams to control dams and vice versa. Postnatal circadian disruption was associated with reduced adult body mass, social avoidance, and hyperactivity. In utero disruption resulted in more pronounced social avoidance and hyperactivity, phenotypes not abrogated by cross-fostering to control mothers. To examine whether circadian disruption affects development by acting as an early life stressor, we examined birthweight, litter size, maternal cannibalism, and epigenetic modifications. None of these variables differed between control and disrupted dams, or resembled patterns seen following early-life stress. Our findings indicate that developmental chronic circadian disruption permanently affects somatic and behavioral development in a stage-of-life-dependent manner, independent of early life stress mechanisms, underscoring the importance of temporal structure during development, both in utero and early postnatal life.Benjamin L. SmarrAzure D. GrantLuz PerezIrving ZuckerLance J. KriegsfeldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benjamin L. Smarr Azure D. Grant Luz Perez Irving Zucker Lance J. Kriegsfeld Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice
description	Abstract Modern life involves chronic circadian disruption through artificial light and these disruptions are associated with numerous mental and physical health maladies. Because the developing nervous system is particularly vulnerable to perturbation, we hypothesized that early-life circadian disruption would negatively impact offspring development and adult function. Pregnant mice were subjected to chronic circadian disruption from the time of uterine implantation through weaning. To dissociate in utero from postnatal effects, a subset of litters was cross-fostered at birth from disrupted dams to control dams and vice versa. Postnatal circadian disruption was associated with reduced adult body mass, social avoidance, and hyperactivity. In utero disruption resulted in more pronounced social avoidance and hyperactivity, phenotypes not abrogated by cross-fostering to control mothers. To examine whether circadian disruption affects development by acting as an early life stressor, we examined birthweight, litter size, maternal cannibalism, and epigenetic modifications. None of these variables differed between control and disrupted dams, or resembled patterns seen following early-life stress. Our findings indicate that developmental chronic circadian disruption permanently affects somatic and behavioral development in a stage-of-life-dependent manner, independent of early life stress mechanisms, underscoring the importance of temporal structure during development, both in utero and early postnatal life.
format	article
author	Benjamin L. Smarr Azure D. Grant Luz Perez Irving Zucker Lance J. Kriegsfeld
author_facet	Benjamin L. Smarr Azure D. Grant Luz Perez Irving Zucker Lance J. Kriegsfeld
author_sort	Benjamin L. Smarr
title	Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice
title_short	Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice
title_full	Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice
title_fullStr	Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice
title_full_unstemmed	Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice
title_sort	maternal and early-life circadian disruption have long-lasting negative consequences on offspring development and adult behavior in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fadafcf1d26349c2a74f8059231cf359
work_keys_str_mv	AT benjaminlsmarr maternalandearlylifecircadiandisruptionhavelonglastingnegativeconsequencesonoffspringdevelopmentandadultbehaviorinmice AT azuredgrant maternalandearlylifecircadiandisruptionhavelonglastingnegativeconsequencesonoffspringdevelopmentandadultbehaviorinmice AT luzperez maternalandearlylifecircadiandisruptionhavelonglastingnegativeconsequencesonoffspringdevelopmentandadultbehaviorinmice AT irvingzucker maternalandearlylifecircadiandisruptionhavelonglastingnegativeconsequencesonoffspringdevelopmentandadultbehaviorinmice AT lancejkriegsfeld maternalandearlylifecircadiandisruptionhavelonglastingnegativeconsequencesonoffspringdevelopmentandadultbehaviorinmice
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Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice

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