Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.

<h4>Background</h4>Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Thiazolidinediones are insulin-sensitizing peroxisome proliferator-activated receptor gamma agonists that are known to affect the morphology of adipose tiss...

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Autores principales:	Jennifer MacKellar, Samuel W Cushman, Vipul Periwal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/faddd2a9802e442281773104489238d7
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spelling	oai:doaj.org-article:faddd2a9802e442281773104489238d72021-11-25T06:27:09ZDifferential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.1932-620310.1371/journal.pone.0008196https://doaj.org/article/faddd2a9802e442281773104489238d72009-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20041138/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Thiazolidinediones are insulin-sensitizing peroxisome proliferator-activated receptor gamma agonists that are known to affect the morphology of adipose tissue.<h4>Methodology</h4>In this study, adipose cell-size probability distributions were measured in six Zucker fa/fa rats over a period of 24 days, from four weeks of age, using micro-biopsies to obtain subcutaneous (inguinal) fat tissue from the animals. Three of the rats were gavaged daily with rosiglitazone, a thiazolidinedione, and three served as controls. These longitudinal probability distributions were analyzed to obtain the rate of increase in cell-size diameter in rosiglitazone-treated animals, and the hyperplasia induced by treatment quantitatively.<h4>Conclusions</h4>We found that treatment leads to hypertrophy that leads to an approximately linear rate of cell diameter increase (2 m/day), and that the hyperplasia evident in treated animals occurs largely within the first eight days of treatment. The availability of additional lipid storage due to treatment may alleviate lipotoxicity and thereby promote insulin sensitivity. The hypothesis that a TZD regimen involving repeated treatments of limited duration may suffice for improvements in insulin sensitivity merits further investigation.Jennifer MacKellarSamuel W CushmanVipul PeriwalPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 12, p e8196 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer MacKellar Samuel W Cushman Vipul Periwal Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.
description	<h4>Background</h4>Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Thiazolidinediones are insulin-sensitizing peroxisome proliferator-activated receptor gamma agonists that are known to affect the morphology of adipose tissue.<h4>Methodology</h4>In this study, adipose cell-size probability distributions were measured in six Zucker fa/fa rats over a period of 24 days, from four weeks of age, using micro-biopsies to obtain subcutaneous (inguinal) fat tissue from the animals. Three of the rats were gavaged daily with rosiglitazone, a thiazolidinedione, and three served as controls. These longitudinal probability distributions were analyzed to obtain the rate of increase in cell-size diameter in rosiglitazone-treated animals, and the hyperplasia induced by treatment quantitatively.<h4>Conclusions</h4>We found that treatment leads to hypertrophy that leads to an approximately linear rate of cell diameter increase (2 m/day), and that the hyperplasia evident in treated animals occurs largely within the first eight days of treatment. The availability of additional lipid storage due to treatment may alleviate lipotoxicity and thereby promote insulin sensitivity. The hypothesis that a TZD regimen involving repeated treatments of limited duration may suffice for improvements in insulin sensitivity merits further investigation.
format	article
author	Jennifer MacKellar Samuel W Cushman Vipul Periwal
author_facet	Jennifer MacKellar Samuel W Cushman Vipul Periwal
author_sort	Jennifer MacKellar
title	Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.
title_short	Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.
title_full	Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.
title_fullStr	Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.
title_full_unstemmed	Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.
title_sort	differential effects of thiazolidinediones on adipocyte growth and recruitment in zucker fatty rats.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/faddd2a9802e442281773104489238d7
work_keys_str_mv	AT jennifermackellar differentialeffectsofthiazolidinedionesonadipocytegrowthandrecruitmentinzuckerfattyrats AT samuelwcushman differentialeffectsofthiazolidinedionesonadipocytegrowthandrecruitmentinzuckerfattyrats AT vipulperiwal differentialeffectsofthiazolidinedionesonadipocytegrowthandrecruitmentinzuckerfattyrats
_version_	1718413719316201472

Differential effects of thiazolidinediones on adipocyte growth and recruitment in Zucker fatty rats.

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