Functional production of a soluble and secreted single-chain antibody by a bacterial secretion system.

Functional production of a soluble and secreted single-chain antibody by a bacterial secretion system.

Single-chain variable fragments (scFvs) serve as an alternative to full-length monoclonal antibodies used in research and therapeutic and diagnostic applications. However, when recombinant scFvs are overexpressed in bacteria, they often form inclusion bodies and exhibit loss of function. To overcome...

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Main Authors: Chiu-Min Cheng, Shey-Cherng Tzou, Ya-Han Zhuang, Chien-Chiao Huang, Chien-Han Kao, Kuang-Wen Liao, Ta-Chun Cheng, Chih-Hung Chuang, Yuan-Chin Hsieh, Ming-Hong Tai, Tian-Lu Cheng
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/fadea00e77d54de7841f016df53dba0a
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https://doaj.org/article/fadea00e77d54de7841f016df53dba0a

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