Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation

Vassilios Kozobolis,1,2 Aristeidis Konstantinidis,1,2 Haris Sideroudi,2 Miguel Teus3 1Department of Ophthalmology, Democritus University of Thrace, Alexandroupolis, Greece; 2Eye Institute of Thrace (EIT), Democritus University of Thrace, Alexandroupolis, Greece; 3University of Alcala, Madrid, Spain...

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Autores principales:	Kozobolis V, Konstantinidis A, Sideroudi H, Teus M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	prostaglandin timolol gel glaucoma fixed combination Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fae26ee7f1d14bc5a92b60c019605ec7
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spelling	oai:doaj.org-article:fae26ee7f1d14bc5a92b60c019605ec72021-12-02T03:19:30ZEfficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation1177-5483https://doaj.org/article/fae26ee7f1d14bc5a92b60c019605ec72018-11-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-the-travoprosttimolol-fixed-combination-versus-the-concomi-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Vassilios Kozobolis,1,2 Aristeidis Konstantinidis,1,2 Haris Sideroudi,2 Miguel Teus3 1Department of Ophthalmology, Democritus University of Thrace, Alexandroupolis, Greece; 2Eye Institute of Thrace (EIT), Democritus University of Thrace, Alexandroupolis, Greece; 3University of Alcala, Madrid, Spain Purpose: To compare the hypotensive effect of travoprost 0.004%/timolol 0.5% fixed combination (TTFC) to the concomitant use of travoprost and timolol 0.1% gel formulation (Trav + Geltim). Materials and methods: Thirty-three patients (62 eyes) were enrolled and divided into two groups. Patients in group 1 (31 eyes) received the TTFC and patients in group 2 (31 eyes) received the concomitant treatment with Trav + Geltim. Patients on previous antiglaucoma treatment discontinued their drops for 2–4 weeks before starting their new treatment (TTFC or Trav + Geltim). The drops were instilled in the evening in group 1 and in group 2, the prostaglandin was installed in the evening, and timolol in the morning. IOP was measured at 1 and 3 months after the initiation of treatment at four time points during the day (09:00, 12:00, 15:00, and 18:00). Results: Both groups showed significant IOP reduction from baseline at all time points at 1 and 3 months. When the two groups were compared, group 2 showed slightly better hypotensive effect that reached statistical significance only at the 18:00 time point at both 1 and 3 months. Conclusion: Both the TTFC and the concomitant use of the travoprost/timolol gel showed similar hypotensive effect with the latter being slightly more potent in reducing the IOP. Keywords: prostaglandin, timolol gel, glaucoma, fixed combinationKozobolis VKonstantinidis ASideroudi HTeus MDove Medical Pressarticleprostaglandintimolol gelglaucomafixed combinationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2393-2398 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostaglandin timolol gel glaucoma fixed combination Ophthalmology RE1-994
spellingShingle	prostaglandin timolol gel glaucoma fixed combination Ophthalmology RE1-994 Kozobolis V Konstantinidis A Sideroudi H Teus M Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation
description	Vassilios Kozobolis,1,2 Aristeidis Konstantinidis,1,2 Haris Sideroudi,2 Miguel Teus3 1Department of Ophthalmology, Democritus University of Thrace, Alexandroupolis, Greece; 2Eye Institute of Thrace (EIT), Democritus University of Thrace, Alexandroupolis, Greece; 3University of Alcala, Madrid, Spain Purpose: To compare the hypotensive effect of travoprost 0.004%/timolol 0.5% fixed combination (TTFC) to the concomitant use of travoprost and timolol 0.1% gel formulation (Trav + Geltim). Materials and methods: Thirty-three patients (62 eyes) were enrolled and divided into two groups. Patients in group 1 (31 eyes) received the TTFC and patients in group 2 (31 eyes) received the concomitant treatment with Trav + Geltim. Patients on previous antiglaucoma treatment discontinued their drops for 2–4 weeks before starting their new treatment (TTFC or Trav + Geltim). The drops were instilled in the evening in group 1 and in group 2, the prostaglandin was installed in the evening, and timolol in the morning. IOP was measured at 1 and 3 months after the initiation of treatment at four time points during the day (09:00, 12:00, 15:00, and 18:00). Results: Both groups showed significant IOP reduction from baseline at all time points at 1 and 3 months. When the two groups were compared, group 2 showed slightly better hypotensive effect that reached statistical significance only at the 18:00 time point at both 1 and 3 months. Conclusion: Both the TTFC and the concomitant use of the travoprost/timolol gel showed similar hypotensive effect with the latter being slightly more potent in reducing the IOP. Keywords: prostaglandin, timolol gel, glaucoma, fixed combination
format	article
author	Kozobolis V Konstantinidis A Sideroudi H Teus M
author_facet	Kozobolis V Konstantinidis A Sideroudi H Teus M
author_sort	Kozobolis V
title	Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation
title_short	Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation
title_full	Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation
title_fullStr	Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation
title_full_unstemmed	Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation
title_sort	efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/fae26ee7f1d14bc5a92b60c019605ec7
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Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation

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