Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort

Abstract Chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, and obstructive sleep apnea (OSA) are amongst the most common treatable and preventable chronic conditions with high morbidity burden and mortality risk. We aimed to explore the exist...

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Autores principales:	Jonás Carmona-Pírez, Beatriz Poblador-Plou, Ignatios Ioakeim-Skoufa, Francisca González-Rubio, Luis Andrés Gimeno-Feliú, Jesús Díez-Manglano, Clara Laguna-Berna, Jose M. Marin, Antonio Gimeno-Miguel, Alexandra Prados-Torres
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fae554ccf06b4b88b225d3137befe3ad
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spelling	oai:doaj.org-article:fae554ccf06b4b88b225d3137befe3ad2021-12-02T15:54:05ZMultimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort10.1038/s41598-021-83964-w2045-2322https://doaj.org/article/fae554ccf06b4b88b225d3137befe3ad2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83964-whttps://doaj.org/toc/2045-2322Abstract Chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, and obstructive sleep apnea (OSA) are amongst the most common treatable and preventable chronic conditions with high morbidity burden and mortality risk. We aimed to explore the existence of multimorbidity clusters in patients with such diseases and to estimate their prevalence and impact on mortality. We conducted an observational retrospective study in the EpiChron Cohort (Aragon, Spain), selecting all patients with a diagnosis of allergic rhinitis, asthma, COPD, and/or OSA. The study population was stratified by age (i.e., 15–44, 45–64, and ≥ 65 years) and gender. We performed cluster analysis, including all chronic conditions recorded in primary care electronic health records and hospital discharge reports. More than 75% of the patients had multimorbidity (co-existence of two or more chronic conditions). We identified associations of dermatologic diseases with musculoskeletal disorders and anxiety, cardiometabolic diseases with mental health problems, and substance use disorders with neurologic diseases and neoplasms, amongst others. The number and complexity of the multimorbidity clusters increased with age in both genders. The cluster with the highest likelihood of mortality was identified in men aged 45 to 64 years and included associations between substance use disorder, neurologic conditions, and cancer. Large-scale epidemiological studies like ours could be useful when planning healthcare interventions targeting patients with chronic obstructive airway diseases and multimorbidity.Jonás Carmona-PírezBeatriz Poblador-PlouIgnatios Ioakeim-SkoufaFrancisca González-RubioLuis Andrés Gimeno-FeliúJesús Díez-ManglanoClara Laguna-BernaJose M. MarinAntonio Gimeno-MiguelAlexandra Prados-TorresNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jonás Carmona-Pírez Beatriz Poblador-Plou Ignatios Ioakeim-Skoufa Francisca González-Rubio Luis Andrés Gimeno-Feliú Jesús Díez-Manglano Clara Laguna-Berna Jose M. Marin Antonio Gimeno-Miguel Alexandra Prados-Torres Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort
description	Abstract Chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, and obstructive sleep apnea (OSA) are amongst the most common treatable and preventable chronic conditions with high morbidity burden and mortality risk. We aimed to explore the existence of multimorbidity clusters in patients with such diseases and to estimate their prevalence and impact on mortality. We conducted an observational retrospective study in the EpiChron Cohort (Aragon, Spain), selecting all patients with a diagnosis of allergic rhinitis, asthma, COPD, and/or OSA. The study population was stratified by age (i.e., 15–44, 45–64, and ≥ 65 years) and gender. We performed cluster analysis, including all chronic conditions recorded in primary care electronic health records and hospital discharge reports. More than 75% of the patients had multimorbidity (co-existence of two or more chronic conditions). We identified associations of dermatologic diseases with musculoskeletal disorders and anxiety, cardiometabolic diseases with mental health problems, and substance use disorders with neurologic diseases and neoplasms, amongst others. The number and complexity of the multimorbidity clusters increased with age in both genders. The cluster with the highest likelihood of mortality was identified in men aged 45 to 64 years and included associations between substance use disorder, neurologic conditions, and cancer. Large-scale epidemiological studies like ours could be useful when planning healthcare interventions targeting patients with chronic obstructive airway diseases and multimorbidity.
format	article
author	Jonás Carmona-Pírez Beatriz Poblador-Plou Ignatios Ioakeim-Skoufa Francisca González-Rubio Luis Andrés Gimeno-Feliú Jesús Díez-Manglano Clara Laguna-Berna Jose M. Marin Antonio Gimeno-Miguel Alexandra Prados-Torres
author_facet	Jonás Carmona-Pírez Beatriz Poblador-Plou Ignatios Ioakeim-Skoufa Francisca González-Rubio Luis Andrés Gimeno-Feliú Jesús Díez-Manglano Clara Laguna-Berna Jose M. Marin Antonio Gimeno-Miguel Alexandra Prados-Torres
author_sort	Jonás Carmona-Pírez
title	Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort
title_short	Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort
title_full	Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort
title_fullStr	Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort
title_full_unstemmed	Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort
title_sort	multimorbidity clusters in patients with chronic obstructive airway diseases in the epichron cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fae554ccf06b4b88b225d3137befe3ad
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Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort

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