Usefulness of milnacipran in treating phantom limb pain

Yasuhide Nagoshi,1 Akira Watanabe,1 Saiko Inoue,1 Tomoki Kuroda,2 Mitsuo Nakamura,3 Yoshitake Matsumoto,4 Kenji Fukui31Department of Psychiatry (Psychosomatic Medicine), Kyoto First Red Cross Hospital, Kyoto, Japan; 2Gojouyama Hospital, Nara, Japan; 3Department of Psychiatry, Graduate School of Medi...

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Autores principales:	Matsumoto Y, Nakamura M, Kuroda T, Inoue S, Watanabe A, Nagoshi Y, Fukui K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fae64bf68a9a4a25a2dda30805bcfa27
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spelling	oai:doaj.org-article:fae64bf68a9a4a25a2dda30805bcfa272021-12-02T01:00:14ZUsefulness of milnacipran in treating phantom limb pain1176-63281178-2021https://doaj.org/article/fae64bf68a9a4a25a2dda30805bcfa272012-11-01T00:00:00Zhttp://www.dovepress.com/usefulness-of-milnacipran-in-treating-phantom-limb-pain-a11556https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Yasuhide Nagoshi,1 Akira Watanabe,1 Saiko Inoue,1 Tomoki Kuroda,2 Mitsuo Nakamura,3 Yoshitake Matsumoto,4 Kenji Fukui31Department of Psychiatry (Psychosomatic Medicine), Kyoto First Red Cross Hospital, Kyoto, Japan; 2Gojouyama Hospital, Nara, Japan; 3Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 4Matsumoto Clinic, Kyoto, JapanBackground: Amputation of an extremity often results in the sensation of a &ldquo;phantom limb&rdquo; where the patient feels that the limb that has been amputated is still present. This is frequently accompanied by &ldquo;phantom limb pain&rdquo;. We report here the use of milnacipran, a serotonin and norepinephrine reuptake inhibitor, to treat phantom limb pain after amputation of injured or diseased limbs in three patients.Methods and results: The severity of phantom pain before and during treatment was quantified using a visual analog scale. In one case, phantom limb pain responded partially to treatment with high doses of paroxetine, and then replacement with milnacipran further improved the pain relief and long-term full pain relief was achieved. In the two other cases, milnacipran was used as first-line treatment and phantom limb pain responded rapidly.Conclusion: These results suggest that milnacipran administration may be useful in phantom limb pain, possibly as a first-line treatment.Keywords: milnacipran, paroxetine, phantom limb pain, selective serotonin reuptake inhibitor (SSRI), serotonin and norepinephrine reuptake inhibitor (SNRI)Matsumoto YNakamura MKuroda TInoue SWatanabe ANagoshi YFukui KDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 549-553 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Matsumoto Y Nakamura M Kuroda T Inoue S Watanabe A Nagoshi Y Fukui K Usefulness of milnacipran in treating phantom limb pain
description	Yasuhide Nagoshi,1 Akira Watanabe,1 Saiko Inoue,1 Tomoki Kuroda,2 Mitsuo Nakamura,3 Yoshitake Matsumoto,4 Kenji Fukui31Department of Psychiatry (Psychosomatic Medicine), Kyoto First Red Cross Hospital, Kyoto, Japan; 2Gojouyama Hospital, Nara, Japan; 3Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 4Matsumoto Clinic, Kyoto, JapanBackground: Amputation of an extremity often results in the sensation of a &ldquo;phantom limb&rdquo; where the patient feels that the limb that has been amputated is still present. This is frequently accompanied by &ldquo;phantom limb pain&rdquo;. We report here the use of milnacipran, a serotonin and norepinephrine reuptake inhibitor, to treat phantom limb pain after amputation of injured or diseased limbs in three patients.Methods and results: The severity of phantom pain before and during treatment was quantified using a visual analog scale. In one case, phantom limb pain responded partially to treatment with high doses of paroxetine, and then replacement with milnacipran further improved the pain relief and long-term full pain relief was achieved. In the two other cases, milnacipran was used as first-line treatment and phantom limb pain responded rapidly.Conclusion: These results suggest that milnacipran administration may be useful in phantom limb pain, possibly as a first-line treatment.Keywords: milnacipran, paroxetine, phantom limb pain, selective serotonin reuptake inhibitor (SSRI), serotonin and norepinephrine reuptake inhibitor (SNRI)
format	article
author	Matsumoto Y Nakamura M Kuroda T Inoue S Watanabe A Nagoshi Y Fukui K
author_facet	Matsumoto Y Nakamura M Kuroda T Inoue S Watanabe A Nagoshi Y Fukui K
author_sort	Matsumoto Y
title	Usefulness of milnacipran in treating phantom limb pain
title_short	Usefulness of milnacipran in treating phantom limb pain
title_full	Usefulness of milnacipran in treating phantom limb pain
title_fullStr	Usefulness of milnacipran in treating phantom limb pain
title_full_unstemmed	Usefulness of milnacipran in treating phantom limb pain
title_sort	usefulness of milnacipran in treating phantom limb pain
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/fae64bf68a9a4a25a2dda30805bcfa27
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Usefulness of milnacipran in treating phantom limb pain

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