Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women

ObjectiveAs the high proportion of underweight pregnant women, omission of their weight gain and blood lipids management during gestation might lead to adverse pregnancy outcomes. This study aimed to determine the relationship between lipid profile and risks for adverse pregnancy outcomes in pre-pre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dongyu Wang, Wenjing Ding, Chengcheng Ding, Haitian Chen, Weihua Zhao, Bo Sun, Zilian Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	underweight cholesterol LGA large for gestational age SGA (small for gestational age) overweight Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/fae7e142e00d4d149e30fbf9aed369bf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fae7e142e00d4d149e30fbf9aed369bf
record_format	dspace
spelling	oai:doaj.org-article:fae7e142e00d4d149e30fbf9aed369bf2021-12-01T08:31:13ZHigher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women1664-239210.3389/fendo.2021.760934https://doaj.org/article/fae7e142e00d4d149e30fbf9aed369bf2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.760934/fullhttps://doaj.org/toc/1664-2392ObjectiveAs the high proportion of underweight pregnant women, omission of their weight gain and blood lipids management during gestation might lead to adverse pregnancy outcomes. This study aimed to determine the relationship between lipid profile and risks for adverse pregnancy outcomes in pre-pregnancy underweight women.MethodsThis study was part of an ongoing cohort study including Chinese gravidas delivered from January 2015 to December 2016. Included subjects were grouped into underweight, normal-weight, and overweight by BMI before conception. Logistic regression was used to assess the association between lipid profiles during second trimester and adverse obstetric outcomes in each group. A subgroup analysis according to the gestational weight gain, in which subjects in each group were divided into above and within the Institute of Medicine (IOM) recommendations, was performed.ResultsA total of 6, 223 women were included. The proportion of underweight (19.3%) was similar to that of overweight women (19.4%) in South China. Peripheral total cholesterol (TC) level in underweight women was significantly higher than that in overweight women (P <0.001). After adjusting maternal age, TC level was positively correlated to the risk for large-for-gestational-age (LGA) [aOR =2.24, 95%CI (1.08, 4.63)], and negatively related to the risk for small-for-gestational age (SGA) [aOR =0.71, 95%CI (0.59, 0.85)] in underweight women, but not in normal-weight or overweight women. The subgroup analysis showed that maternal TC level was positively correlated with the risk of LGA only in underweight women who gained weight more than the IOM recommendations.ConclusionUnderweight pregnant women with high TC levels had a higher risk for LGA, especially among women whose gestational weight gain were above the IOM recommendations. Therefore, clinical management of lipids and weight gain during gestation should also be recommended for underweight women.Dongyu WangWenjing DingChengcheng DingHaitian ChenWeihua ZhaoBo SunZilian WangFrontiers Media S.A.articleunderweightcholesterolLGA large for gestational ageSGA (small for gestational age)overweightDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	underweight cholesterol LGA large for gestational age SGA (small for gestational age) overweight Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	underweight cholesterol LGA large for gestational age SGA (small for gestational age) overweight Diseases of the endocrine glands. Clinical endocrinology RC648-665 Dongyu Wang Wenjing Ding Chengcheng Ding Haitian Chen Weihua Zhao Bo Sun Zilian Wang Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women
description	ObjectiveAs the high proportion of underweight pregnant women, omission of their weight gain and blood lipids management during gestation might lead to adverse pregnancy outcomes. This study aimed to determine the relationship between lipid profile and risks for adverse pregnancy outcomes in pre-pregnancy underweight women.MethodsThis study was part of an ongoing cohort study including Chinese gravidas delivered from January 2015 to December 2016. Included subjects were grouped into underweight, normal-weight, and overweight by BMI before conception. Logistic regression was used to assess the association between lipid profiles during second trimester and adverse obstetric outcomes in each group. A subgroup analysis according to the gestational weight gain, in which subjects in each group were divided into above and within the Institute of Medicine (IOM) recommendations, was performed.ResultsA total of 6, 223 women were included. The proportion of underweight (19.3%) was similar to that of overweight women (19.4%) in South China. Peripheral total cholesterol (TC) level in underweight women was significantly higher than that in overweight women (P <0.001). After adjusting maternal age, TC level was positively correlated to the risk for large-for-gestational-age (LGA) [aOR =2.24, 95%CI (1.08, 4.63)], and negatively related to the risk for small-for-gestational age (SGA) [aOR =0.71, 95%CI (0.59, 0.85)] in underweight women, but not in normal-weight or overweight women. The subgroup analysis showed that maternal TC level was positively correlated with the risk of LGA only in underweight women who gained weight more than the IOM recommendations.ConclusionUnderweight pregnant women with high TC levels had a higher risk for LGA, especially among women whose gestational weight gain were above the IOM recommendations. Therefore, clinical management of lipids and weight gain during gestation should also be recommended for underweight women.
format	article
author	Dongyu Wang Wenjing Ding Chengcheng Ding Haitian Chen Weihua Zhao Bo Sun Zilian Wang
author_facet	Dongyu Wang Wenjing Ding Chengcheng Ding Haitian Chen Weihua Zhao Bo Sun Zilian Wang
author_sort	Dongyu Wang
title	Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women
title_short	Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women
title_full	Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women
title_fullStr	Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women
title_full_unstemmed	Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women
title_sort	higher peripheral cholesterol and a positive correlation with risk for large-for-gestational-age neonates in pre-pregnancy underweight women
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fae7e142e00d4d149e30fbf9aed369bf
work_keys_str_mv	AT dongyuwang higherperipheralcholesterolandapositivecorrelationwithriskforlargeforgestationalageneonatesinprepregnancyunderweightwomen AT wenjingding higherperipheralcholesterolandapositivecorrelationwithriskforlargeforgestationalageneonatesinprepregnancyunderweightwomen AT chengchengding higherperipheralcholesterolandapositivecorrelationwithriskforlargeforgestationalageneonatesinprepregnancyunderweightwomen AT haitianchen higherperipheralcholesterolandapositivecorrelationwithriskforlargeforgestationalageneonatesinprepregnancyunderweightwomen AT weihuazhao higherperipheralcholesterolandapositivecorrelationwithriskforlargeforgestationalageneonatesinprepregnancyunderweightwomen AT bosun higherperipheralcholesterolandapositivecorrelationwithriskforlargeforgestationalageneonatesinprepregnancyunderweightwomen AT zilianwang higherperipheralcholesterolandapositivecorrelationwithriskforlargeforgestationalageneonatesinprepregnancyunderweightwomen
_version_	1718405393056530432

Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women

Ejemplares similares